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Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase
Abstract
The phenomenon of posttranscriptional gene silencing (PTGS), which occurs when a transgene is introduced into a cell, is poorly understood. Here, the qde-3 gene, which is required for the activation and maintenance of gene silencing in the fungus Neurospora crassa , was isolated. Sequence analysis revealed that the qde-3 gene belongs to the RecQ DNA helicase family. The QDE3 protein may function in the DNA-DNA interaction between introduced transgenes or with an endogenous gene required for gene-silencing activation. In animals, genes that are homologous to RecQ protein, such as the human genes for Bloom's syndrome and Werner's syndrome, may also function in PTGS.
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Cited by
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Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R., & Hannon, G. J. (2001) · Science · doi:10.1126/science.1064023 · Cited by 1,580
RNA Interference: Biology, Mechanism, and Applications
Agrawal, N., Dasaradhi, P. V. N., Mohmmed, A., Malhotra, P., Bhatnagar, R. K., & Mukherjee, S. K. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.657-685.2003 · Cited by 1,305
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes & Development · doi:10.1101/gad.974702 · Cited by 1,105
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Metadata
- Authors
- Cogoni, C., & Macino, G.
- Venue
- Science
- Published
- 1999-12-17
- Volume
- 286
- Issue
- 5448
- Pages
- 2342-2344
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970535781
- Cited by
- 246
- References
- 0
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cogoni, C., & Macino, G. (1999). Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase. Science. https://doi.org/10.1126/science.286.5448.2342
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
