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Use of the Cell Wall Precursor Lipid II by a Pore-Forming Peptide Antibiotic
Open accessAbstract
Resistance to antibiotics is increasing in some groups of clinically important pathogens. For instance, high vancomycin resistance has emerged in enterococci. Promising alternative antibiotics are the peptide antibiotics, abundant in host defense systems, which kill their targets by permeabilizing the plasma membrane. These peptides generally do not act via specific receptors and are active in the micromolar range. Here it is shown that vancomycin and the antibacterial peptide nisin Z use the same target: the membrane-anchored cell wall precursor Lipid II. Nisin combines high affinity for Lipid II with its pore-forming ability, thus causing the peptide to be highly active (in the nanomolar range).
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Citations
Cited by
Bacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380
Bacteriocins: safe, natural antimicrobials for food preservation.
Cleveland, J., Montville, T. J., Nes, I. F., & Chikindas, M. L. (2001) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00560-8 · Cited by 1,835
Preservation and Fermentation: Past, Present and Future
Paul Ross, R., Morgan, S., & Hill, C. (2002) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00174-5 · Cited by 942
Bacteriocins of lactic acid bacteria: Extending the family
Alvarez-Sieiro, P., Montalbán-López, M., Mu, D., & Kuipers, O. P. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7343-9 · Cited by 729
Self-citationPrinciples of assessing bacterial susceptibility to antibiotics using the agar diffusion method
Bonev, B., Hooper, J., & Parisot, J. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn090 · Cited by 644
Metadata
- Authors
- Breukink, E., Wiedemann, I., Kraaij, C. V., Kuipers, O. P., Sahl, H.-G., & de Kruijff, B.
- Venue
- Science
- Published
- 1999-12-17
- Volume
- 286
- Issue
- 5448
- Pages
- 2361-2364
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968125869
- Cited by
- 814
- References
- 0
- FWCI
- 18.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Breukink, E., Wiedemann, I., Kraaij, C. V., Kuipers, O. P., Sahl, H.-G., & de Kruijff, B. (1999). Use of the Cell Wall Precursor Lipid II by a Pore-Forming Peptide Antibiotic. Science. https://doi.org/10.1126/science.286.5448.2361
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
