The DOI matches its Crossref record.
Genetic Definition and Sequence Analysis of Arabidopsis Centromeres
Abstract
High-precision genetic mapping was used to define the regions that contain centromere functions on each natural chromosome in Arabidopsis thaliana. These regions exhibited dramatic recombinational repression and contained complex DNA surrounding large arrays of 180–base pair repeats. Unexpectedly, the DNA within the centromeres was not merely structural but also encoded several expressed genes. The regions flanking the centromeres were densely populated by repetitive elements yet experienced normal levels of recombination. The genetically defined centromeres were well conserved among Arabidopsis ecotypes but displayed limited sequence homology between different chromosomes, excluding repetitive DNA. This investigation provides a platform for dissecting the role of individual sequences in centromeres in higher eukaryotes.
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Citations
Cited by
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301
Effects of inbreeding on the genetic diversity of populations
Charlesworth, D. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2003.1296 · Cited by 466
Structural Dynamics of Eukaryotic Chromosome Evolution
Eichler, E. E., & Sankoff, D. (2003) · Science · doi:10.1126/science.1086132 · Cited by 406
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters
Choi, K., Zhao, X., Kelly, K. A., Venn, O., Higgins, J. D., Yelina, N. E., Hardcastle, T. J., Ziolkowski, P. A., Copenhaver, G. P., Franklin, F. C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2766 · Cited by 375
Self-citationYelina, N. E., Lambing, C., Hardcastle, T. J., Zhao, X., Santos, B., & Henderson, I. R. (2015) · Genes & Development · doi:10.1101/gad.270876.115 · Cited by 198
Metadata
- Authors
- Copenhaver, G. P., Nickel, K., Kuromori, T., Benito, M.-I., Kaul, S., Lin, X., Bevan, M., Murphy, G., Harris, B., Parnell, L. D., McCombie, W. R., Martienssen, R. A., Marra, M., & Preuss, D.
- Venue
- Science
- Published
- 1999-12-24
- Volume
- 286
- Issue
- 5449
- Pages
- 2468-2474
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2129774153
- Cited by
- 413
- References
- 0
- FWCI
- 44.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Copenhaver, G. P., Nickel, K., Kuromori, T., Benito, M.-I., Kaul, S., Lin, X., Bevan, M., Murphy, G., Harris, B., Parnell, L. D., McCombie, W. R., Martienssen, R. A., Marra, M., & Preuss, D. (1999). Genetic Definition and Sequence Analysis of Arabidopsis Centromeres. Science. https://doi.org/10.1126/science.286.5449.2468
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