The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pharmacological Rescue of Mutant p53 Conformation and Function
Abstract
Compounds that stabilize the DNA binding domain of p53 in the active conformation were identified. These small synthetic molecules not only promoted the stability of wild-type p53 but also allowed mutant p53 to maintain an active conformation. A prototype compound caused the accumulation of conformationally active p53 in cells with mutant p53, enabling it to activate transcription and to slow tumor growth in mice. With further work aimed at improving potency, this class of compounds may be developed into anticancer drugs of broad utility.
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In the citing paper
“CP31398 administration can recover the transcriptional activity of partial mutant p53 and inhibit the thermal denaturation of wild-type p53 because of its Michael acceptor characteristics.313”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [313]
In the citing paper
“CP31398 was the first compound discovered that can reactivate mutant p53.”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [313]
In the citing paper
“For example, CP-31398 was initially thought to maintain the wild-type conformation of the mutant p53,454 but was shown to be unable to bind p53 in a different lab.455”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [454]
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Citations
Cites
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551
Cited by
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Drug Discovery: A Historical Perspective
Drews, J. (2000) · Science · doi:10.1126/science.287.5460.1960 · Cited by 2,760
Johnstone (2002) · doi:10.1016/s0092-8674(02)00625-6 · Cited by 1,876
The RB and p53 pathways in cancer
Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690
Muller, P. A. J., & Vousden, K. H. (2013) · Nature Cell Biology · doi:10.1038/ncb2641 · Cited by 1,647
Metadata
- Authors
- Foster, B. A., Coffey, H. A., Morin, M. J., & Rastinejad, F.
- Venue
- Science
- Published
- 1999-12-24
- Volume
- 286
- Issue
- 5449
- Pages
- 2507-2510
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058769115
- Cited by
- 799
- References
- 1
- FWCI
- 18.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Foster, B. A., Coffey, H. A., Morin, M. J., & Rastinejad, F. (1999). Pharmacological Rescue of Mutant p53 Conformation and Function. Science. https://doi.org/10.1126/science.286.5449.2507
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
