Transgenic Mouse Model of Stunned Myocardium

Molecular and Cellular Mechanisms of Myocardial Stunning

Bolli, R., & Marbán, E. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.609 · Cited by 1,044 · see citing works

Continuous measurement of left ventricular volume in animals and humans by conductance catheter.

Baan, J., van der Velde, E. T., de Bruin, H. G., Smeenk, G. J., Koops, J., van Dijk, A. D., Temmerman, D., Senden, J. M., & Buis, B. (1984) · Circulation · doi:10.1161/01.cir.70.5.812 · Cited by 899 · see citing works

Actin Mutations in Dilated Cardiomyopathy, a Heritable Form of Heart Failure

Olson, T. M., Michels, V. V., Thibodeau, S. N., Tai, Y.-S., & Keating, M. T. (1998) · Science · doi:10.1126/science.280.5364.750 · Cited by 621 · see citing works

Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

Kimura, A., Harada, H., Park, J.-E., Nishi, H., Satoh, M., Takahashi, M., Hiroi, S., Sasaoka, T., Ohbuchi, N., Nakamura, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0897-379 · Cited by 576 · see citing works

A Mouse Model of Familial Hypertrophic Cardiomyopathy

Geisterfer-Lowrance, A. A. T., Christe, M. E., Conner, D. A., Ingwall, J. S., Schöen, F. J., Seidman, C. E., & Seidman, J. G. (1996) · Science · doi:10.1126/science.272.5262.731 · Cited by 554 · see citing works

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

Subramaniam, A., Jones, W. K., Gulick, J. M., Wert, S. E., Neumann, J. C., & Robbins, J. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54273-3 · Cited by 470 · see citing works

α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy

Mogensen, J., Klausen, I. C., Pedersen, A. K., Egeblad, H., Bross, P., Kruse, T. A., Gregersen, N., HANSEN, P. S., Baandrup, U. T., & Børglum, A. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6460 · Cited by 396 · see citing works

Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium

Gao, W. D., Atar, D., Liu, Y., et al. (1997) · Circulation Research · doi:10.1161/01.res.0000435855.49359.47 · Cited by 392 · see citing works

Troponin I Degradation and Covalent Complex Formation Accompanies Myocardial Ischemia/Reperfusion Injury

McDonough, J. L., Arrell, D. K., & Eyk, J. E. V. (1999) · Circulation Research · doi:10.1161/01.res.84.1.9 · Cited by 318 · see citing works

Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation

Becker, L. C., Levine, J. H., DiPaula, A., et al. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80468-5 · Cited by 278 · see citing works

The role of cytoskeletal proteins in cardiomyopathies

Towbin, J. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80096-3 · Cited by 273 · see citing works

Breakdown and Release of Myofilament Proteins During Ischemia and Ischemia/Reperfusion in Rat Hearts

Eyk, J. E. V., Powers, F. G., Law, W. R., Larue, C., Hodges, R. S., & Solaro, R. J. (1998) · Circulation Research · doi:10.1161/01.res.82.2.261 · Cited by 234 · see citing works

Relationship Between Intracellular Calcium and Contractile Force in Stunned Myocardium

Gao, W. D., Atar, D., Backx, P. H., et al. (1995) · Circulation Research · doi:10.1161/01.res.76.6.1036 · Cited by 221 · see citing works

Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart

Fentzke, R. C., Buck, S. H., Patel, J. R., et al. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0143z.x · Cited by 220 · see citing works

Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional deterioration

Bolli, R., Zhu, W.-X., Myers, M. L., et al. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90413-8 · Cited by 219 · see citing works

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

Jones, W. K., Grupp, I. L., Doetschman, T., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118992 · Cited by 204 · see citing works

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.

Tardiff, J. C., Factor, S. M., Tompkins, B., Hewett, T. E., Palmer, B. M., Moore, R. L., Schwartz, S. D., Robbins, J. M., & Leinwand, L. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2389 · Cited by 193 · see citing works

Troponin I isoform expression in human heart.

Hunkeler, N. M., Kullman, J., & Murphy, A. M. (1991) · Circulation Research · doi:10.1161/01.res.69.5.1409 · Cited by 177 · see citing works

The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?

Lehrer, S. S. (1994) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf00123476 · Cited by 174 · see citing works

Intrinsic Myofilament Alterations Underlying the Decreased Contractility of Stunned Myocardium

Gao, W. D., Liu, Y., Mellgren, R. L., et al. (1996) · Circulation Research · doi:10.1161/01.res.78.3.455 · Cited by 158 · see citing works

Cellular Mechanisms Of Myocardial Stunning

Kusuoka, H., & Marbán, E. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.001331 · Cited by 153 · see citing works

The pathogenesis of familial hypertrophic cardiomyopathy: Early and evolving effects from an α-cardiac myosin heavy chain missense mutation

Georgakopoulos, D., Christe, M. E., Giewat, M., Seidman, C. E., Seidman, J. G., & Kass, D. A. (1999) · Nature Medicine · doi:10.1038/6549 · Cited by 133 · see citing works

Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 2

Sanbe, A., Fewell, J. G., Gulick, J. M., Osińska, H. E., Lorenz, J. N., Hall, D. G., Murray, L. A., Kimball, T. R., Witt, S. A., & Robbins, J. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21085 · Cited by 123 · see citing works

Calcium cycling and contractile activation in intact mouse cardiac muscle

Gao, W. D., Pérez, N. G., & Marbán, E. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.175bu.x · Cited by 121 · see citing works

The C Terminus of Cardiac Troponin I Is Essential for Full Inhibitory Activity and Ca2+ Sensitivity of Rat Myofibrils

Rarick, H. M., Tu, X.-H., Solaro, R. J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.26887 · Cited by 107 · see citing works

Absence of Troponin I Degradation or Altered Sarcoplasmic Reticulum Uptake Protein Expression After Reversible Ischemia in Swine

Thomas, S. A., Fallavollita, J. A., Lee, T., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.5.446 · Cited by 80 · see citing works

Altered cardiac excitation–contraction coupling in mutant mice with familial hypertrophic cardiomyopathy

Gao, W. D., Pérez, N. G., Seidman, C. E., Seidman, J. G., & Marbán, E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5220 · Cited by 58 · see citing works

Mapping Subdomains in the C-terminal Region of Troponin I Involved in Its Binding to Troponin C and to Thin Filament

Ramos, C. H. I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18189 · Cited by 56 · see citing works

Molecular mechanisms regulating the myofilament response to Ca2+: Implications of mutations causal for familial hypertrophic cardiomyopathy

Palmiter, K. A., & Solaro, R. J. (1997) · Basic Research in Cardiology · doi:10.1007/bf00794070 · Cited by 47 · see citing works

Incorporation of the Troponin Regulatory Complex of Post-ischemic Stunned Porcine Myocardium Reduces Myofilament Calcium Sensitivity in Rabbit Psoas Skeletal Muscle Fibers

McDonald, K. S., Moss, R. L., & Miller, W. P. (1998) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0603 · Cited by 29 · see citing works

In Search of the Proteins That Cause Myocardial Stunning

Foster, D. B., & Eyk, J. E. V. (1999) · Circulation Research · doi:10.1161/01.res.85.5.470 · Cited by 26 · see citing works

Angiotensin-converting enzyme 2 is an essential regulator of heart function

Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733 · see citing works

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

Okazaki, T., Tanaka, Y., Nishio, R., Mitsuiye, T., Mizoguchi, A., Wang, J., Ishida, M., Hiai, H., Matsumori, A., Minato, N., et al. (2003) · Nature Medicine · doi:10.1038/nm955 · Cited by 689 · see citing works

Extensive Troponin I and T Modification Detected in Serum From Patients With Acute Myocardial Infarction

Labugger, R., Organ, L., Collier, C., Atar, D., & Van Eyk, J. E. (2000) · Circulation · doi:10.1161/01.cir.102.11.1221 · Cited by 315 · see citing works

Top-Down Quantitative Proteomics Identified Phosphorylation of Cardiac Troponin I as a Candidate Biomarker for Chronic Heart Failure

Zhang, J., Guy, M. J., Norman, H. S., Chen, Y.-C., Xu, Q., Dong, X., Guner, H., Wang, S., Kohmoto, T., Young, K. H., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200258m · Cited by 194 · see citing works

Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I–Mediated Apoptosis

Li, G. H., Shi, Y., Chen, Y., Sun, M., Sader, S., Maekawa, Y., Arab, S., Dawood, F., Chen, M., De Couto, G., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.172882 · Cited by 90 · see citing works

Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

Tiambeng, T. N., Roberts, D. S., Brown, K. A., Zhu, Y., Chen, B., Wu, Z., Mitchell, S. D., Guardado-Alvarez, T. M., Jin, S., & Ge, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-17643-1 · Cited by 76 · see citing works

Developing the next generation of cardiac markers: Disease-induced modifications of troponin I

McDonough, J. L., & Van Eyk, J. E. (2004) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2004.07.001 · Cited by 62 · see citing works

The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

Soetkamp, D., Raedschelders, K., Mastali, M., Sobhani, K., Bairey Merz, C. N., & Van Eyk, J. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1387054 · Cited by 36 · see citing works

Localization of Regions of Troponin I Important in Deactivation of Cardiac Myofilaments by Acidic pH

Li, G., Martin, A. F., & Solaro, J. R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1392 · Cited by 31 · see citing works

Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres

Dvornikov, A. V., Smolin, N., Zhang, M., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.746172 · Cited by 36 · see citing works

Abstract 109: Site-specific Acetylation of Cardiac Troponin I Regulates Myofilament Relaxation and Calcium Sensitivity

Woulfe, K. C., Lin, Y. H., Schmidt, W., et al. (2019) · Circulation Research · doi:10.1161/res.125.suppl_1.109

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity

Lin, Y. H., Schmidt, W., Fritz, K. S., Jeong, M. Y., Cammarato, A., Foster, D. B., Biesiadecki, B. J., McKinsey, T. A., & Woulfe, K. C. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.01.007 · Cited by 28 · see citing works

Differential effects of pH on calcium activation of myofilaments of adult and perinatal dog hearts. Evidence for developmental differences in thin filament regulation.

JSolaro, R., PKumar, MBlanchard, E., et al. (1986) · Circulation Research