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A Critical Role for Murine Complement Regulator Crry in Fetomaternal Tolerance
Abstract
Complement is a component of natural immunity. Its regulation is needed to protect tissues from inflammation, but mice with a disrupted gene for the complement regulator decay accelerating factor were normal. Mice that were deficient in another murine complement regulator, Crry, were generated to investigate its role in vivo. Survival of Crry −/− embryos was compromised because of complement deposition and concomitant placenta inflammation. Complement activation at the fetomaternal interface caused the fetal loss because breeding to C3 −/− mice rescued Crry −/− mice from lethality. Thus, the regulation of complement is critical in fetal control of maternal processes that mediate tissue damage.
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Citations
Cited by
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Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
The preterm parturition syndrome
Romero, R., Espinoza, J., Kusanovic, J., Gotsch, F., Hassan, S., Erez, O., Chaiworapongsa, T., & Mazor, M. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01120.x · Cited by 1,419
Immunology of placentation in eutherian mammals
Moffett, A., & Loke, C. (2006) · Nature Reviews Immunology · doi:10.1038/nri1897 · Cited by 836
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 587
Gene expression patterns in human placenta
Sood, R., Zehnder, J. L., Druzin, M. L., & Brown, P. O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508035103 · Cited by 454
Metadata
- Authors
- Xu, C., Mao, D., Holers, V. M., Palanca, B., Cheng, A. M., & Molina, H.
- Venue
- Science
- Published
- 2000-01-21
- Volume
- 287
- Issue
- 5452
- Pages
- 498-501
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1659820601
- Cited by
- 524
- References
- 0
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, C., Mao, D., Holers, V. M., Palanca, B., Cheng, A. M., & Molina, H. (2000). A Critical Role for Murine Complement Regulator Crry in Fetomaternal Tolerance. Science. https://doi.org/10.1126/science.287.5452.498
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
