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A Tale of Two Futures: HIV and Antiretroviral Therapy in San Francisco
Abstract
The effect of antiretroviral therapy (ART) in preventing human immunodeficiency virus (HIV) infections and averting acquired immunodeficiency syndrome (AIDS) deaths in the San Francisco gay community over the next 10 years was predicted. A transmission model was coupled with a statistical approach that enabled inclusion of a high degree of uncertainty in the potential treatment effects of ART (in terms of infectivity and survival), increase in risky behavior, and rate of emergence of drug resistance. Increasing the usage of ART in San Francisco would decrease the AIDS death rate and could substantially reduce the incidence rate.
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Cited by
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Funk, S., Salathé, M., & Jansen, V. A. A. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0142 · Cited by 1,314
Montaner, J. S., Lima, V. D., Barrios, R., Yip, B., Wood, E., Kerr, T., Shannon, K., Harrigan, P. R., Hogg, R. S., Daly, P., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60936-1 · Cited by 780
Montaner, J. S., Hogg, R., Wood, E., Kerr, T., Tyndall, M., Levy, A. R., & Harrigan, P. R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69162-9 · Cited by 555
Wood, E., Kerr, T., Marshall, B. D. L., Li, K., Zhang, R., Hogg, R. S., Harrigan, P. R., & Montaner, J. S. G. (2009) · BMJ · doi:10.1136/bmj.b1649 · Cited by 342
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Sato, M., Motomura, T., Aramaki, H., Matsuda, T., Yamashita, M., Ito, Y., Kawakami, H., Matsuzaki, Y., Watanabe, W., Yamataka, K., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0600139 · Cited by 328
Metadata
- Authors
- Blower, S. M., Gershengorn, H. B., & Grant, R. M.
- Venue
- Science
- Published
- 2000-01-28
- Volume
- 287
- Issue
- 5453
- Pages
- 650-654
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001111303
- Cited by
- 390
- References
- 0
- FWCI
- 18.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blower, S. M., Gershengorn, H. B., & Grant, R. M. (2000). A Tale of Two Futures: HIV and Antiretroviral Therapy in San Francisco. Science. https://doi.org/10.1126/science.287.5453.650
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.