The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study
Open accessAbstract
OBJECTIVE: To examine the relation between plasma HIV-1 RNA concentrations in the community and HIV incidence among injecting drug users. DESIGN: Prospective cohort study. SETTING: Inner city community in Vancouver, Canada. PARTICIPANTS: Injecting drug users, with and without HIV, followed up every six months between 1 May 1996 and 30 June 2007. MAIN OUTCOME MEASURES: Estimated community plasma HIV-1 RNA in the six months before each HIV negative participant's follow-up visit. Associated HIV incidence. RESULTS: Among 622 injecting drug users with HIV, 12 435 measurements of plasma HIV-1 RNA were obtained. Among 1429 injecting drug users without HIV, there were 155 HIV seroconversions, resulting in an incidence density of 2.49 (95% confidence interval 2.09 to 2.88) per 100 person years. In a Cox model that adjusted for unsafe sexual behaviours and sharing used syringes, the estimated community plasma HIV-1 RNA concentration remained independently associated with the time to HIV seroconversion (hazard ratio 3.32 (1.82 to 6.08, P<0.001), per log(10) increase). When the follow-up period was limited to observations after 1 January 1988 (when the median plasma HIV RNA concentration was <20 000 copies/ml), the median viral load was no longer statistically associated with HIV incidence (1.70 (0.79 to 3.67, P=0.175), per log(10) increase). CONCLUSIONS: A longitudinal measure of community plasma HIV-1 RNA concentration was correlated with the community HIV incidence rate and predicted HIV incidence independent of unsafe sexual behaviours and sharing used syringes. If these findings are confirmed, they could help to inform both HIV prevention and treatment interventions.
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Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1
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Needle exchange is not enough: lessons from the Vancouver injecting drug use study
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Self-citationMontaner, J. S., Hogg, R., Wood, E., Kerr, T., Tyndall, M., Levy, A. R., & Harrigan, P. R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69162-9 · Cited by 555
Self-citationBarriers to Use of Free Antiretroviral Therapy in Injection Drug Users
Strathdee, S. A. (1998) · JAMA · doi:10.1001/jama.280.6.547 · Cited by 505
A Tale of Two Futures: HIV and Antiretroviral Therapy in San Francisco
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Changes in pathological findings at autopsy in AIDS cases for the last 15 years
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Safer injection facility use and syringe sharing in injection drug users
Kerr, T., Tyndall, M., Li, K., Montaner, J., & Wood, E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66475-6 · Cited by 294
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Montaner, J. S., Lima, V. D., Barrios, R., Yip, B., Wood, E., Kerr, T., Shannon, K., Harrigan, P. R., Hogg, R. S., Daly, P., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60936-1 · Cited by 780
Self-citationPublic health and international drug policy
Csete, J., Kamarulzaman, A., Kazatchkine, M., Altice, F., Balicki, M., Buxton, J., Cepeda, J., Comfort, M., Goosby, E., Goulão, J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00619-x · Cited by 641
Self-citationMilloy, M.-J., Kerr, T., Bangsberg, D. R., Buxton, J., Parashar, S., Guillemi, S., Montaner, J., & Wood, E. (2012) · AIDS Patient Care and STDs · doi:10.1089/apc.2011.0169 · Cited by 112
Self-citationChou, R., Selph, S., Dana, T., Bougatsos, C., Zakher, B., Blazina, I., & Korthuis, P. T. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-10-201211200-00007 · Cited by 46
Metadata
- Authors
- Wood, E., Kerr, T., Marshall, B. D. L., Li, K., Zhang, R., Hogg, R. S., Harrigan, P. R., & Montaner, J. S. G.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2009-04-30
- Volume
- 338
- Issue
- apr30 1
- Pages
- b1649-b1649
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W1991565490
- Cited by
- 342
- References
- 27
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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