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Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion
Abstract
The Gram-negative bacterium Helicobacter pylori is a causative agent of gastritis and peptic ulcer disease in humans. Strains producing the CagA antigen ( cagA + ) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma. We show here that such strains translocate the bacterial protein CagA into gastric epithelial cells by a type IV secretion system, encoded by the cag pathogenicity island. CagA is tyrosine-phosphorylated and induces changes in the tyrosine phosphorylation state of distinct cellular proteins. Modulation of host cells by bacterial protein translocation adds a new dimension to the chronic Helicobacter infection with yet unknown consequences.
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Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Helicobacter pylori: gastric cancer and beyond
Polk, D. B., & Peek, R. M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2857 · Cited by 1,158
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Plottel, C. S., & Blaser, M. J. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.003 · Cited by 743
Host-Bacterial Interactions in Helicobacter pylori Infection
Amieva, M. R., & El–Omar, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.009 · Cited by 632
Metadata
- Authors
- Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., & Haas, R.
- Venue
- Science
- Published
- 2000-02-25
- Volume
- 287
- Issue
- 5457
- Pages
- 1497-1500
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088902653
- Cited by
- 1,286
- References
- 0
- FWCI
- 86.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., & Haas, R. (2000). Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion. Science. https://doi.org/10.1126/science.287.5457.1497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
