The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Porphyrin and Phthalocyanine Antiscrapie Compounds
Abstract
The transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases for which no effective treatments are available. The likelihood that a bovine form of TSE has crossed species barriers and infected humans underscores the urgent need to identify anti-TSE drugs. Certain cyclic tetrapyrroles (porphyrins and phthalocyanines) have recently been shown to inhibit the in vitro formation of PrP-res, a protease-resistant protein critical for TSE pathogenesis. We now report that treatment of TSE-infected animals with three such compounds increased survival time from 50 to 300%. The significant inhibition of TSE disease by structurally dissimilar tetrapyrroles identifies these compounds as anti-TSE drugs.
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Cites
A new variant of Creutzfeldt-Jakob disease in the UK
Will, R. G., Ironside, J. W., Zeidler, M., Estibeiro, K., Cousens, S. N., Smith, P. G., Alperovitch, A., Poser, S., Pocchiari, M., & Hofman, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91412-9 · Cited by 2,707
Pan, K. M., Baldwin, M., Nguyen, J., Gasset, M., Serban, A., Groth, D., Mehlhorn, I., Huang, Z., Fletterick, R. J., & Cohen, F. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10962 · Cited by 2,277
Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy
Bonnett, R. (1995) · Chemical Society Reviews · doi:10.1039/cs9952400019 · Cited by 2,039
Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent
Bruce, M. E., Will, R. G., Ironside, J. W., McConnell, I., Drummond, D., Suttie, A., McCardle, L., Chree, A., Hope, J., Birkett, C., et al. (1997) · Nature · doi:10.1038/39057 · Cited by 1,967
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
Collinge, J., Sidle, K. C. L., Meads, J., Ironside, J., & Hill, A. F. (1996) · Nature · doi:10.1038/383685a0 · Cited by 1,735
Cell-free formation of protease-resistant prion protein
Kocisko, D. A., Come, J. H., Priola, S. A., Chesebro, B., Raymond, G. J., Lansbury, P. T., & Caughey, B. (1994) · Nature · doi:10.1038/370471a0 · Cited by 883
Self-citationCaughey, B. W., Dong, A., Bhat, K. S., Ernst, D., Hayes, S. F., & Caughey, W. S. (1991) · Biochemistry · doi:10.1021/bi00245a003 · Cited by 822
Self-citationCaughey, B., & Raymond, G. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55257-1 · Cited by 637
Manson, J. C., Clarke, A. R., Hooper, M. L., Aitchison, L., McConnell, I., & Hope, J. (1994) · Molecular Neurobiology · doi:10.1007/bf02780662 · Cited by 581
Borchelt, D. R., Scott, M., Taraboulos, A., Stahl, N., & Prusiner, S. B. (1990) · The Journal of cell biology · doi:10.1083/jcb.110.3.743 · Cited by 504
Cited by
Neurodegenerative Diseases and Prions
Prusiner, S. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105173442006 · Cited by 772
Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis
Mallucci, G., Dickinson, A., Linehan, J., Klöhn, P.-C., Brandner, S., & Collinge, J. (2003) · Science · doi:10.1126/science.1090187 · Cited by 770
A systematic review of prion therapeutics in experimental models
Trevitt, C. R. (2006) · Brain · doi:10.1093/brain/awl150 · Cited by 263
Antimicrobial properties of porphyrins
Stojiljkovic, I., Evavold, B. D., & Kumar, V. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.2.309 · Cited by 209
Metadata
- Authors
- Priola, S. A., Raines, A., & Caughey, W. S.
- Venue
- Science
- Published
- 2000-02-25
- Volume
- 287
- Issue
- 5457
- Pages
- 1503-1506
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969868345
- Cited by
- 302
- References
- 20
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Priola, S. A., Raines, A., & Caughey, W. S. (2000). Porphyrin and Phthalocyanine Antiscrapie Compounds. Science. https://doi.org/10.1126/science.287.5457.1503
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
