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An Ultrasensitive Bacterial Motor Revealed by Monitoring Signaling Proteins in Single Cells
Abstract
Understanding biology at the single-cell level requires simultaneous measurements of biochemical parameters and behavioral characteristics in individual cells. Here, the output of individual flagellar motors in Escherichia coli was measured as a function of the intracellular concentration of the chemotactic signaling protein. The concentration of this molecule, fused to green fluorescent protein, was monitored with fluorescence correlation spectroscopy. Motors from different bacteria exhibited an identical steep input-output relation, suggesting that they actively contribute to signal amplification in chemotaxis. This experimental approach can be extended to quantitative in vivo studies of other biochemical networks.
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Citations
Cited by
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Ideker, T., Galitski, T., & Hood, L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.343 · Cited by 1,664
The Rotary Motor of Bacterial Flagella
Berg, H. C. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161737 · Cited by 1,457
Gene Regulation at the Single-Cell Level
Rosenfeld, N., Young, J. W., Alon, U., Swain, P. S., & Elowitz, M. B. (2005) · Science · doi:10.1126/science.1106914 · Cited by 1,104
Robustness of cellular functions
Stelling, J., Sauer, U., Szallasi, Z., Doyle, F. J., & Doyle, J. (2004) · Cell · doi:10.1016/j.cell.2004.09.008 · Cited by 1,049
Real-Time Observation of Transcription Initiation and Elongation on an Endogenous Yeast Gene
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Metadata
- Authors
- Cluzel, P., Surette, M., & Leibler, S.
- Venue
- Science
- Published
- 2000-03-03
- Volume
- 287
- Issue
- 5458
- Pages
- 1652-1655
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026078372
- Cited by
- 606
- References
- 0
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- closed
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