The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dual Signaling Regulated by Calcyon, a D1 Dopamine Receptor Interacting Protein
Abstract
The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor–expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G q - and G s -coupled heterotrimeric GTP–binding protein–coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca 2+ i ) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca 2+ -dependent signaling should provide insight into the D1 receptor–modulated cognitive functions of prefrontal cortex.
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Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593
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Cited by
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Neve, K. A., Seamans, J. K., & Trantham‐Davidson, H. (2004) · Journal of Receptors and Signal Transduction · doi:10.1081/lrst-200029981 · Cited by 837
Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
Goldman-Rakic, P., Castner, S., Svensson, T., Siever, L., & Williams, G. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1793-y · Cited by 544
Self-citationLee, F. J. S., Xue, S., Pei, L., Vukusic, B., Chéry, N., Wang, Y., Wang, Y. T., Niznik, H. B., Yu, X.-M., & Liu, F. (2002) · Cell · doi:10.1016/s0092-8674(02)00962-5 · Cited by 542
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514
Metadata
- Authors
- Lezcano, N., Mrzljak, L., Eubanks, S., Levenson, R., Goldman-Rakic, P., & Bergson, C.
- Venue
- Science
- Published
- 2000-03-03
- Volume
- 287
- Issue
- 5458
- Pages
- 1660-1664
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069203092
- Cited by
- 175
- References
- 1
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- Lezcano, N., Mrzljak, L., Eubanks, S., Levenson, R., Goldman-Rakic, P., & Bergson, C. (2000). Dual Signaling Regulated by Calcyon, a D1 Dopamine Receptor Interacting Protein. Science. https://doi.org/10.1126/science.287.5458.1660
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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