Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Abstract
Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dopamine depletion or antagonism impairs visuospatial working memory.
“evidence from non‐human primates (Sawaguchi & Goldman‐Rakic, 1991, 1994; Williams & Goldmanrakic, 1995) and in healthy humans (Fischer et al., 2010) showed that dopamine depletion or antagonism impairs visuospatial WM.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Williams & Goldmanrakic, 1995
Dopamine exerts a significant influence over prefrontal cortical functions such as working memory, in a manner that depends on initial levels or efficacy of this neuromodulator.
“Third, dopamine exerts a significant influence over prefrontal cortical functions such as working memory (Williams and Goldman-Rakic, 1995), in a manner that depends on initial levels or efficacy of this neuromodulator (Cools and D’Esposito, 2011).”
From Goals and Habits in the Brain (2013) · cites this paper as Williams and Goldman-Rakic, 1995
D1 dopaminergic receptors modulate response amplitude and selectivity in dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks.
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [205]
Dopaminergic signalling has a role in top-down regulation of spatial attention.
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [205]
It is consistent with a growing literature documenting baseline performance-dependent effects of stimulants and related drugs, which have been explained by a hypothesized inverted U-shaped function, whereby optimal catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired performance.
“It is also consistent with a growing literature documenting baseline performance-dependent effects of stimulants and related drugs, which have been explained by a hypothesized inverted U-shaped function, whereby optimal catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired performance (Robbins and Sahakian, 1979; N”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Williams and Goldman-Rakic, 1995
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,377 · see citing works
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685 · see citing works
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500 · see citing works
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364 · see citing works
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 946 · see citing works
Dopamine receptors and the dopamine hypothesis of schizophrenia
Seeman, P. M. (1987) · Synapse · doi:10.1002/syn.890010203 · Cited by 880 · see citing works
Molecular cloning and expression of the gene for a human D1 dopamine receptor
Dearry, A., Gingrich, J. A., Falardeau, P., Fremeau, R. T., Bates, M. D., & Caron, M. G. (1990) · Nature · doi:10.1038/347072a0 · Cited by 674 · see citing works
Molecular Diversity of the Dopamine Receptors
Civelli, O., Bunzow, J. R., & Grandy, D. K. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.001433 · Cited by 623 · see citing works
Lange, K. W., Robbins, T. W., MARSDEN, C. D., James-Galton, M., Owen, A. M., & Paul, G. M. (1992) · Psychopharmacology · doi:10.1007/bf02245167 · Cited by 608 · see citing works
Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates
Berger, B., Gaspar, P., & Verney, C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90179-x · Cited by 588 · see citing works
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566 · see citing works
Self-citationCepeda, C., Buchwald, N. A., & Levine, M. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9576 · Cited by 554 · see citing works
Molecular Diversity of the Dopamine Receptors
Civelli, O. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.33.1.281 · Cited by 510 · see citing works
Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms
Funahashi, S., Bruce, C. J., & Goldman‐Rakic, P. S. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.4.814 · Cited by 443 · see citing works
Self-citationCellular and circuit basis of working memory in prefrontal cortex of nonhuman primates.
Goldman-Rakic, P. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62688-6 · Cited by 443 · see citing works
Self-citationDopamine synaptic complex with pyramidal neurons in primate cerebral cortex.
Goldman-Rakic, P. S., Leranth, C., Williams, S. M., Mons, N. E., & Geffard, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9015 · Cited by 433 · see citing works
Self-citationLidow, M. S., Goldman-Rakic, P. S., Gallager, D. W., & Rakic, P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90003-7 · Cited by 394 · see citing works
Smiley, J. F., Levey, A. I., Ciliax, B. J., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5720 · Cited by 383 · see citing works
Self-citationXu, M., Hu, X.-T., Cooper, D. C., Moratalla, R., Graybiel, A., White, F. J., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90026-4 · Cited by 347 · see citing works
Altered striatal function in a mutant mouse lacking D1A dopamine receptors.
Drago, J., Gerfen, C. R., Lachowicz, J. E., Steiner, H., Hollon, T. R., Love, P. E., Ooi, G. T., Grinberg, A., Lee, E. J. K., & Huang, S.-P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12564 · Cited by 343 · see citing works
Benson, D. F. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.10.1400-a · Cited by 329 · see citing works
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303 · see citing works
Self-citationCarroll, B. J., & Barrett, J. E. (1991) · Medical Entomology and Zoology · Cited by 278 · see citing works
Daniel, D., Weinberger, D. R., Jones, D. W., Zigun, J. R., Coppola, R., Handel, S. F., Bigelow, L. B., Goldberg, T., Berman, K. F., & Kleinman, J. E. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-01907.1991 · Cited by 277 · see citing works
van Eden, C. G., Hoorneman, E. M. D., Buijs, R. M., Matthijssen, M. A. H., Geffard, M., & Uylings, H. B. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)92964-2 · Cited by 272 · see citing works
Facilitation of Working Memory in Humans by a D2 Dopamine Receptor Agonist
Luciana, M. M., Depue, R. A., Arbisi, P. A., & Leon, A. S. (1992) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1992.4.1.58 · Cited by 269 · see citing works
Calabresi, P., Mercuri, N. B., Stanzione, P., Stefani, A., & Bernardi, G. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90239-9 · Cited by 261 · see citing works
Arnsten, A. F. T., Cai, J., Steere, J. C., & Goldman-Rakic, P. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03429.1995 · Cited by 254 · see citing works
Self-citationSawaguchi, T., Matsumura, M., & Kubota, K. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.6.1401 · Cited by 199 · see citing works
Chipkin, R. E., Iorio, L. C., Coffin, V. L., McQuade, R. D., Berger, J. G., & Barnett, A. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13263-1 · Cited by 182 · see citing works
Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex
Cepeda, C., Radisavljevic, Z., Peacock, W. J., Levine, M. S., & Buchwald, N. A. (1992) · Synapse · doi:10.1002/syn.890110408 · Cited by 171 · see citing works
Séguéla, P., Watkins, K. C., & Descarries, L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91427-8 · Cited by 157 · see citing works
Visuospatial working memory in Parkinson's disease.
Bradley, V. A., Welch, J. L., & Dick, D. J. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.11.1228 · Cited by 151 · see citing works
Tyrosine reverses a cold-induced working memory deficit in humans
Shurtleff, D., Thomas, J. R., Schrot, J., Kowalski, K., & Harford, R. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90299-2 · Cited by 142 · see citing works
Godbout, R., Mantz, J., Pirot, S., Glowinski, J., & Thierry, A. M. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20466-9 · Cited by 97 · see citing works
Effects of dopaminergic drugs on working and reference memory in rats
Bushnell, P. J., & Levin, E. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90119-e · Cited by 71 · see citing works
Goldstein, L. E., Rasmusson, A. M., Bunney, B., & Rh, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04937.1994 · Cited by 65 · see citing works
Millar, J., & Williams, G. V. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902870109 · Cited by 53 · see citing works
Self-citationEffects of d-Amphetamine and prefrontal cortical cooling on delayed matching-to-sample behavior
Bauer, R. H., & Fuster, J. M. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90311-8 · Cited by 39 · see citing works
Influence of the Mesocortical/Prefrontal Dopamine Neurons on Their Target Cellsa
Thierry, A. M., Mantz, J., Milla, C., & Glowinski, J. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42099.x · Cited by 32 · see citing works
The binding of SCH 39166 and SCH 23390 to 5-HT1C receptors in porcine choroid plexus
Taylor, L. A., Tedford, C. E., & McQuade, R. D. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90051-c · Cited by 20 · see citing works
Ultra-low noise silver-plated carbon fibre microelectrodes
Millar, J., & Williams, G. V. (1988) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(88)90120-3 · Cited by 20 · see citing works
Self-citationSCH 23390 decreases self-stimulation of the medial prefrontal cortex in the rat
Sabater, R., Saez, J., & Jm, F. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90082-s · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Barkley, R. A. (1997) · Psychological Bulletin · doi:10.1037//0033-2909.121.1.65 · Cited by 580 · see citing works
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027 · see citing works
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
A neuropsychological theory of positive affect and its influence on cognition.
Ashby, F. G., Isen, A. M., & Turken, A. U. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.529 · Cited by 2,270 · see citing works
The prefontral cortex and cognitive control
Miller, E. K. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036228 · Cited by 2,016 · see citing works
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673 · see citing works
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722 · see citing works
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Training and plasticity of working memory
Klingberg, T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.002 · Cited by 1,585 · see citing works
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545 · see citing works
Diamond, A. D. (2000) · Child Development · doi:10.1111/1467-8624.00117 · Cited by 1,509 · see citing works
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415 · see citing works
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works
Compte, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.9.910 · Cited by 1,143 · see citing works
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216 · see citing works
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
Pierce, R. C., & Kalivas, P. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00021-0 · Cited by 1,239 · see citing works
Dopamine and the regulation of cognition and attention
Nieoullon, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00011-4 · Cited by 1,131 · see citing works
Amit, D. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.3.237 · Cited by 1,061 · see citing works
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013 · see citing works
Self-citationThe Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia
Meltzer, H. Y., & McGurk, S. R. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033376 · Cited by 1,022 · see citing works
Hyperpolarization-Activated Cation Channels: From Genes to Function
Biel, M., Wahl‐Schott, C., Michalakis, S., & Zong, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00029.2008 · Cited by 1,005 · see citing works
Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988 · see citing works
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation
Robbins, T. W., & Arnsten, A. F. T. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135535 · Cited by 957 · see citing works
Dolan, R. J., & Dayan, P. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.007 · Cited by 977 · see citing works
Cools, R. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.12.1136 · Cited by 906 · see citing works
Behavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918 · see citing works
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909 · see citing works
Self-citationFriston, K. J. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00140-0 · Cited by 882 · see citing works
Multiple Parallel Memory Systems in the Brain of the Rat
White, N. M., & McDonald, R. J. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4008 · Cited by 888 · see citing works
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893 · see citing works
An adaptive coding model of neural function in prefrontal cortex
Duncan, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35097575 · Cited by 874 · see citing works
Brain development, gender and IQ in children
Reiss, A. L., Abrams, M. T., Singer, H. S., ROSS, J. L., & DENCKLA, M. B. (1996) · Brain · doi:10.1093/brain/119.5.1763 · Cited by 867 · see citing works
Regional and cellular fractionation of working memory
Goldman‐Rakic, P. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13473 · Cited by 810 · see citing works
Self-citationD1 receptors in prefrontal cells and circuits
Goldman-Rakic, P. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00045-4 · Cited by 807 · see citing works
Self-citationCools, R. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.024 · Cited by 903 · see citing works
Serotonin receptors : their key role in drugs to treat schizophrenia
Meltzer, H. Y., Li, Z., Kaneda, Y., & Ichikawa, J. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.010 · Cited by 778 · see citing works
The correlative triad among aging, dopamine, and cognition: Current status and future prospects
Bäckman, L., Nyberg, L. H., Lindenberger, U., Li, S., & Farde, L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.005 · Cited by 761 · see citing works
Prefrontal neurons and the genetics of schizophrenia
Weinberger, D. R., Egan, M. F., Bertolino, A., Callicott, J. H., Mattay, V. S., Lipska, B. K., Berman, K. F., & Goldberg, T. E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01252-5 · Cited by 744 · see citing works
A model of saccade generation based on parallel processing and competitive inhibition
Findlay, J. M., & Walker, R. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002150 · Cited by 730 · see citing works
Barth, C., Villringer, A., & Sacher, J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00037 · Cited by 731 · see citing works
Keefe, R. S. E., Silva, S. G., Perkins, D. O., & Lieberman, J. A. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033374 · Cited by 690 · see citing works
del Campo, N., Chamberlain, S. R., Sahakian, B. J., & Robbins, T. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.036 · Cited by 685 · see citing works
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
Tunbridge, E. M., Harrison, P. J., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.024 · Cited by 685 · see citing works
Javitt, D. C., Steinschneider, M., Schroeder, C. E., & Arezzo, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11962 · Cited by 662 · see citing works
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia
Goldman-Rakic, P. S., & Selemon, L. D. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.437 · Cited by 668 · see citing works
Self-citationZahrt, J., Taylor, J. R., Mathew, R. G., & Arnsten, A. F. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08528.1997 · Cited by 796 · see citing works
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
Alex, K. D., & Pehek, E. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.004 · Cited by 658 · see citing works
Segregation of working memory functions within the dorsolateral prefrontal cortex
Lévy, R., & Goldman, P. S. (2000) · Experimental Brain Research · doi:10.1007/s002210000397 · Cited by 641 · see citing works
Expectation of reward modulates cognitive signals in the basal ganglia
Kawagoe, R., Takikawa, Y., & Hikosaka, O. (1998) · Nature Neuroscience · doi:10.1038/1625 · Cited by 632 · see citing works
A theory of cognitive control, aging cognition, and neuromodulation
Braver, T. S., & Barch, D. M. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00067-2 · Cited by 629 · see citing works
Bridging emotion theory and neurobiology through dynamic systems modeling
Lewis, M. D. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0500004x · Cited by 618 · see citing works
Brunel, N., & Wang, X.-J. (2001) · Journal of Computational Neuroscience · doi:10.1023/a:1011204814320 · Cited by 620 · see citing works
Dopamine-Mediated Stabilization of Delay-Period Activity in a Network Model of Prefrontal Cortex
Durstewitz, D., Seamans, J. K., & B, T. J. S. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1733 · Cited by 617 · see citing works
Catecholamine modulation of prefrontal cortical cognitive function
Arnsten, A. F. T. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01240-6 · Cited by 608 · see citing works
Durstewitz, D., & Seamans, J. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.015 · Cited by 586 · see citing works
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia
Winterer, G., & Weinberger, D. R. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.002 · Cited by 598 · see citing works
Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1325 · Cited by 590 · see citing works
Self-citationMacPherson, S. E., Phillips, L. H., & Sala, S. D. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.4.598 · Cited by 590 · see citing works
Miyamoto, S., Miyake, N., Jarskog, L. F., Fleischhacker, W. W., & Lieberman, J. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.47 · Cited by 576 · see citing works
Dopamine: a potential substrate for synaptic plasticity and memory mechanisms
Jay, T. M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00085-6 · Cited by 576 · see citing works
Dopamine and Cognitive Control in Prefrontal Cortex
Ott, T., & Nieder, A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.12.006 · Cited by 530 · see citing works
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., et al. (1997) · Nature · doi:10.1038/385634a0 · Cited by 710 · see citing works
LUPIEN, S. J., Gillin, C. J., & Hauger, R. L. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.3.420 · Cited by 561 · see citing works
Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546 · see citing works
Changes in cortical dopamine D1 receptor binding associated with cognitive training
McNab, F., Varrone, A., Farde, L., Jucaite, A., Bystritsky, P., Forssberg, H., & Klingberg, T. (2009) · Science · doi:10.1126/science.1166102 · Cited by 545 · see citing works
Non-spatially lateralized mechanisms in hemispatial neglect
Husain, M., & Rorden, C. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1005 · Cited by 536 · see citing works
Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538 · see citing works
Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527 · see citing works
Brunel, N., & Wang, X. (2014) · Journal of Computational Neuroscience · doi:10.1007/s10827-014-0506-8 · Cited by 538 · see citing works
Cools, R., Barker, R. A., Sahakian, B. J., & Robbins, T. W. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00117-9 · Cited by 516 · see citing works
Dopamine: 50 years in perspective
Iversen, S. D., & Iversen, L. L. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.002 · Cited by 514 · see citing works
Neural Activity in the Primate Prefrontal Cortex during Associative Learning
Asaad, W. F., Rainer, G., & Miller, E. K. (1998) · Neuron · doi:10.1016/s0896-6273(00)80658-3 · Cited by 593 · see citing works
Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks
Arnsten, A. F. T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.027 · Cited by 493 · see citing works
A 4 Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activities
Fujisawa, S., & Buzsáki, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.018 · Cited by 501 · see citing works
Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry
Owen, A. M. (2004) · The Neuroscientist · doi:10.1177/1073858404266776 · Cited by 496 · see citing works
Frank, M. J., & O'Reilly, R. C. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.3.497 · Cited by 472 · see citing works
Cohen, J. D., Braver, T. S., & O´Reilly, R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0138 · Cited by 487 · see citing works
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W., Snyder, G. L., Nishi, A., Chéramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., et al. (1998) · Science · doi:10.1126/science.281.5378.838 · Cited by 491 · see citing works
Neuronal mechanisms of executive control by the prefrontal cortex
Funahashi, S. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(00)00224-8 · Cited by 493 · see citing works
Catecholamine regulation of the prefrontal cortex
Arnsten, A. F. T. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100208 · Cited by 489 · see citing works
Stimulants: Therapeutic Actions in ADHD
Arnsten, A. F. T. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301164 · Cited by 473 · see citing works
A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia
Simpson, E. H., Kellendonk, C., & Kandel, E. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.014 · Cited by 478 · see citing works
Dopamine: generalization and bonuses
Kakade, S. M., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00048-5 · Cited by 477 · see citing works
Pharmacology and behavioral pharmacology of the mesocortical dopamine system
Tzschentke, T. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00033-2 · Cited by 481 · see citing works
The endophenotype concept in psychiatric genetics
FLINT, J., & MUNAFÒ, M. R. (2007) · Psychological Medicine · doi:10.1017/s0033291706008750 · Cited by 477 · see citing works
Royall, D. R., Lauterbach, E. C., Cummings, J. L., Reeve, A., Rummans, T. A., Kaufer, D., LaFrance, W. C., Jr., & Coffey, C. E. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.4.377 · Cited by 790 · see citing works
Serotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462 · see citing works
Seamans, J. K., Floresco, S., & Phillips, A. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01613.1998 · Cited by 472 · see citing works
Widespread origin of the primate mesofrontal dopamine system.
Williams, S. M., & Goldman-Rakic, P. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.4.321 · Cited by 481 · see citing works
Opponency revisited: competition and cooperation between dopamine and serotonin
Boureau, Y.-L., & Dayan, P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.151 · Cited by 456 · see citing works
Linking Mind and Brain in the Study of Mental Illnesses: A Project for a Scientific Psychopathology
Andreasen, N. C. (1997) · Science · doi:10.1126/science.275.5306.1586 · Cited by 451 · see citing works
Leon, M. I., & Shadlen, M. N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80854-5 · Cited by 449 · see citing works
Role of the lateral prefrontal cortex in executive behavioral control.
Tanji, J., & Hoshi, E. (2008) · Physiological Reviews · doi:10.1152/physrev.00014.2007 · Cited by 495 · see citing works
What, If Anything, Is Rodent Prefrontal Cortex?
Laubach, M., Amarante, L. M., Swanson, K., & White, S. R. (2018) · eNeuro · doi:10.1523/eneuro.0315-18.2018 · Cited by 449 · see citing works
Mesocortical dopamine modulation of executive functions: beyond working memory
Floresco, S. B., & Magyar, O. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0404-5 · Cited by 426 · see citing works
Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity
Gu, Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00026-x · Cited by 518 · see citing works
A role for NMDA-receptor channels in working memory
Lisman, J. E., Fellous, J., & Wang, X. (1998) · Nature Neuroscience · doi:10.1038/1086 · Cited by 438 · see citing works
HCN channels: Structure, cellular regulation and physiological function
Wahl‐Schott, C., & Biel, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8525-0 · Cited by 438 · see citing works
- Authors
- Williams, G. V., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- ORCID
- Williams, Graham V.
- Venue
- Nature
- Published
- 1995-08
- Volume
- 376
- Issue
- 6541
- Pages
- 572-575
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2084007108
- Cited by
- 1,593
- References
- 42
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 27 · 2018: 37 · 2017: 33 · 2016: 48 · 2015: 63 · 2014: 45 · 2013: 78 · 2012: 74
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dopamine D1 receptor, working memory, prefrontal cortex, memory field, dopamine D1 receptor antagonist, synaptic modulation, excitatory synaptic input, iontophoresis, single-unit recording
- MeSH terms
- Animals, Haplorhini, Dose-Response Relationship, Drug, Iontophoresis, Memory, Neurons, Psychomotor Performance, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
