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Transplantation of Fetal Hematopoietic Stem Cells in Utero: The Creation of Hematopoietic Chimeras
Abstract
Transplantation of normal, immature, fetal hematopoietic cells into a preimmune fetal recipient with a congenital hemoglobinopathy may allow partial reconstitution of normal hemoglobin production without the complications associated with postnatal bone marrow transplantation (immunosuppression and the occurrence of graft versus host disease). In order to test this hypothesis the naturally occurring polymorphism at the β-hemoglobin locus of the sheep was used as a marker for engraftment and hematopoietic chimerism. Intraperitoneal injection of allogeneic fetal stem cells into normal fetal lambs resulted in hematopoietic chimerism in three of four surviving recipients. This chimerism has been sustained for 6 months after birth and 9 months after engraftment, without evidence of graft versus host disease, and without the use of immunosuppressive therapy.
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Cited by
Flake, A. W., Roncarolo, M.-G., Puck, J. M., Almeida-Porada, G., Evans, M. I., Johnson, M. P., Abella, E. M., Harrison, D. D., & Zanjani, E. D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612123352404 · Cited by 339
Self-citationLorenz, H. P. (2003) · Frontiers in Bioscience · doi:10.2741/1183 · Cited by 268
Riley, J. S., McClain, L. E., Stratigis, J. D., Coons, B. E., Ahn, N. J., Li, H., Loukogeorgakis, S. P., Fachin, C. G., Dias, A. I. B. S., Flake, A. W., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001208 · Cited by 17
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Metadata
- Authors
- Flake, A. W., Harrison, M. R., Adzick, N. S., & Zanjani, E. D.
- Venue
- Science
- Published
- 1986-08-15
- Volume
- 233
- Issue
- 4765
- Pages
- 776-778
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971624034
- Cited by
- 230
- References
- 0
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Flake, A. W., Harrison, M. R., Adzick, N. S., & Zanjani, E. D. (1986). Transplantation of Fetal Hematopoietic Stem Cells in Utero: The Creation of Hematopoietic Chimeras. Science. https://doi.org/10.1126/science.2874611
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
