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Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative Disorders
Abstract
A novel human B-lymphotropic virus (HBLV) was isolated from the peripheral blood leukocytes of six individuals: two HTLV-III seropositive patients from the United States (one with AIDS-related lymphoma and one with dermatopathic lymphadenopathy), three HTLV-III seronegative patients from the United States (one with angioimmunoblastic lymphadenopathy, one with cutaneous T-cell lymphoma, and one with immunoblastic lymphoma), and one HTLV-III seronegative patient with acute lymphocytic leukemia from Jamaica. All six isolates were closely related by antigenic analysis, and sera from all six virus-positive patients reacted immunologically with each virus isolate. In contrast, only four sera from 220 randomly selected healthy donors and none from 12 AIDS patients without associated lymphoma were seropositive. The virus selectively infected freshly isolated human B cells and converted them into large, refractile mono- or binucleated cells with nuclear and cytoplasmic inclusion bodies. HBLV is morphologically similar to viruses of the herpesvirus family but is readily distinguishable from the known human and nonhuman primate herpesviruses by host range, in vitro biological effects, and antigenic features.
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Citations
Cited by
IDENTIFICATION OF HUMAN HERPESVIRUS-6 AS A CAUSAL AGENT FOR EXANTHEM SUBITUM
Yamanishi, K., Shiraki, K., Kondo, T., Okuno, T., Takahashi, M., Asano, Y., & Kurata, T. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91893-4 · Cited by 1,455
CD46 Is a Cellular Receptor for Human Herpesvirus 6
Santoro, F., Kennedy, P. E., Locatelli, G., Malnati, M. S., Berger, E. A., & Lusso, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81678-5 · Cited by 522
Latent human herpesvirus 6 infection of human monocytes/macrophages
Kondo, K., Kondo, T., Okuno, T., Takahashi, M., & Yamanishi, K. (1991) · Journal of General Virology · doi:10.1099/0022-1317-72-6-1401 · Cited by 341
Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections
Agut, H., Bonnafous, P., & Gautheret-Dejean, A. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00122-14 · Cited by 345
Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A
Dominguez, G., Dambaugh, T. R., Stamey, F. R., Dewhurst, S., Inoue, N., & Pellett, P. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8040-8052.1999 · Cited by 339
Metadata
- Authors
- Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B., & Gallo, R. C.
- Venue
- Science
- Published
- 1986-10-31
- Volume
- 234
- Issue
- 4776
- Pages
- 596-601
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963829537
- Cited by
- 1,428
- References
- 0
- FWCI
- 27.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative Disorders. https://app.cochat.ai/papers/10.1126/science.2876520
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- Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B., & Gallo, R. C. (1986). Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative Disorders. Science. https://doi.org/10.1126/science.2876520
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