Latent human herpesvirus 6 infection of human monocytes/macrophages
Abstract
Human herpesvirus 6 (HHV-6) DNA was detected in peripheral blood from exanthem subitum patients during the acute and convalescent phases of infection using the polymerase chain reaction. Although DNA could be detected in non-adherent and adherent mononuclear cells during the acute phase, it was detected predominantly in adherent cells during the convalescent phase; furthermore, viral DNA was found in adherent cells of healthy adults. When adherent mononuclear cells were cultured in vitro, virus was found to replicate well in differentiated cells cultured for 7 days in vitro before infection. When cells were cultured for more than 1 month, no detectable antigen and no evidence of virus growth was observed, but viral DNA could be detected. These apparently latently infected monocytes were treated with phorbol ester, after which virus could be recovered from the cultures. Therefore, we have developed an in vitro latency system for HHV-6; our results suggest that HHV-6 may latently infect monocytes in vivo and in vitro and that it may be reactivated in cells by some factors.
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Under certain circumstances, usually immunosuppressive states, HHV-6 can reactivate and exert a cytopathic effect.
“Under certain circumstances, usually immunosuppressive states, the virus can reactivate and exert a cytopathic effect [6].”
From Human Herpesvirus 6—A Rare Aetiologic Agent for CNS Infections in Immunocompetent Individuals or an Underestimation? (2024) · cites this paper as [6]
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- Authors
- Kondo, K., Kondo, T., Okuno, T., Takahashi, M., & Yamanishi, K.
- Affiliations
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 1991-06-01
- Volume
- 72
- Issue
- 6
- Pages
- 1401-1408
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2158864742
- Cited by
- 341
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 11
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of General Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- human herpesvirus 6, viral latency, monocytes, macrophages, exanthem subitum, viral DNA detection, phorbol ester, viral reactivation
- MeSH terms
- Adult, Antigens, Viral, Base Sequence, Cell Adhesion, Cells, Cultured, DNA, Viral, Fluorescent Antibody Technique, Herpesviridae Infections, Humans, Macrophages, Molecular Sequence Data, Monocytes, Reference Values, Tetradecanoylphorbol Acetate, Time Factors, Virus Activation, Oligonucleotide Probes, Herpesvirus 6, Human, Polymerase Chain Reaction
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