The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons
Abstract
Long-range regulatory elements are difficult to discover experimentally; however, they tend to be conserved among mammals, suggesting that cross-species sequence comparisons should identify them. To search for regulatory sequences, we examined about 1 megabase of orthologous human and mouse sequences for conserved noncoding elements with greater than or equal to 70% identity over at least 100 base pairs. Ninety noncoding sequences meeting these criteria were discovered, and the analysis of 15 of these elements found that about 70% were conserved across mammals. Characterization of the largest element in yeast artificial chromosome transgenic mice revealed it to be a coordinate regulator of three genes, interleukin-4 , interleukin-13 , and interleukin-5 , spread over 120 kilobases.
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Self-citationImpaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells
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Metadata
- Authors
- Loots, G. G., Locksley, R. M., Blankespoor, C. M., Wang, Z. E., Miller, W., Rubin, E. M., & Frazer, K. A.
- Venue
- Science
- Published
- 2000-04-07
- Volume
- 288
- Issue
- 5463
- Pages
- 136-140
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999909705
- Cited by
- 783
- References
- 11
- FWCI
- 27.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loots, G. G., Locksley, R. M., Blankespoor, C. M., Wang, Z. E., Miller, W., Rubin, E. M., & Frazer, K. A. (2000). Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons. Science. https://doi.org/10.1126/science.288.5463.136
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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