The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
Open accessAbstract
A backbone model of a 10-subunit yeast RNA polymerase II has been derived from x-ray diffraction data extending to 3 angstroms resolution. All 10 subunits exhibit a high degree of identity with the corresponding human proteins, and 9 of the 10 subunits are conserved among the three eukaryotic RNA polymerases I, II, and III. Notable features of the model include a pair of jaws, formed by subunits Rpb1, Rpb5, and Rpb9, that appear to grip DNA downstream of the active center. A clamp on the DNA nearer the active center, formed by Rpb1, Rpb2, and Rpb6, may be locked in the closed position by RNA, accounting for the great stability of transcribing complexes. A pore in the protein complex beneath the active center may allow entry of substrates for polymerization and exit of the transcript during proofreading and passage through pause sites in the DNA.
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[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
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Laity, J. H., Lee, B. M., & Wright, P. E. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00167-6 · Cited by 1,534
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
Cramer, P., Bushnell, D. A., & Kornberg, R. D. (2001) · Science · doi:10.1126/science.1059493 · Cited by 1,247
Self-citationElongation by RNA polymerase II: the short and long of it
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Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways
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Metadata
- Authors
- Cramer, P., Bushnell, D. A., Fu, J., Gnatt, A. L., Maier-Davis, B., Thompson, N. E., Burgess, R. R., Edwards, A. M., David, P. R., & Kornberg, R. D.
- Venue
- Science
- Published
- 2000-04-28
- Volume
- 288
- Issue
- 5466
- Pages
- 640-649
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005744558
- Cited by
- 627
- References
- 1
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Cramer, P., Bushnell, D. A., Fu, J., Gnatt, A. L., Maier-Davis, B., Thompson, N. E., Burgess, R. R., Edwards, A. M., David, P. R., & Kornberg, R. D. (2000). Architecture of RNA Polymerase II and Implications for the Transcription Mechanism. Science. https://doi.org/10.1126/science.288.5466.640
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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