The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Psychological and Neural Mechanisms of the Affective Dimension of Pain
Abstract
The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect. Experimental and clinical studies show serial interactions between pain sensation intensity, pain unpleasantness, and secondary affect. These pain dimensions and their interactions relate to a central network of brain structures that processes nociceptive information both in parallel and in series. Spinal pathways to limbic structures and medial thalamic nuclei provide direct inputs to brain areas involved in affect. Another source is from spinal pathways to somatosensory thalamic and cortical areas and then through a cortico-limbic pathway. The latter integrates nociceptive input with contextual information and memory to provide cognitive mediation of pain affect. Both direct and cortico-limbic pathways converge on the same anterior cingulate cortical and subcortical structures whose function may be to establish emotional valence and response priorities.
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“both lateral and medial systems thought to mediate “sensory” versus “affective” aspects of pain (e.g., S2/dpINS and dACC/aINS, respectively) are strongly responsive to nociceptive input [13],[71].”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [71]
In the citing paper
“This is supported by human imaging studies revealing that social disconnection engages brain regions including the dorsal anterior cingulate cortex and anterior insula cortex190, which also process the affective component of physical pain191.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [191]
Citations
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Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
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Cited by
Sorted by citations
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Parshall, M. B., Schwartzstein, R. M., Adams, L., Banzett, R. B., Manning, H. L., Bourbeau, J., Calverley, P. M., Gift, A. G., Harver, A., Lareau, S. C., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201111-2042st · Cited by 1,844
Metadata
- Authors
- Price, D. D.
- Affiliations
- University of Florida (US)
- Corresponding author
- Price, Donald D.
- ORCID
- Price, Donald D.
- Venue
- Science
- Published
- 2000-06-09
- Volume
- 288
- Issue
- 5472
- Pages
- 1769-1772
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007791604
- Cited by
- 2,092
- References
- 25
- Citations by year
- 2026: 50 · 2025: 67 · 2024: 60 · 2023: 77 · 2022: 95 · 2021: 93 · 2020: 88 · 2019: 114 · 2018: 86 · 2017: 88 · 2016: 102 · 2015: 81 · 2014: 79 · 2013: 103 · 2012: 83
- FWCI
- 26.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R01 295527912)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- affective dimension of pain, pain unpleasantness, nociception, anterior cingulate cortex, medial thalamic nuclei, emotional valence, pain memory
- MeSH terms
- Affect, Afferent Pathways, Animals, Brain Mapping, Cerebral Cortex, Humans, Limbic System, Pain, Parietal Lobe, Somatosensory Cortex, Spinal Cord, Thalamic Nuclei, Tomography, Emission-Computed
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