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Psychological and Neural Mechanisms of the Affective Dimension of Pain

Price, Donald D.·2000·Science

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Abstract

The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect. Experimental and clinical studies show serial interactions between pain sensation intensity, pain unpleasantness, and secondary affect. These pain dimensions and their interactions relate to a central network of brain structures that processes nociceptive information both in parallel and in series. Spinal pathways to limbic structures and medial thalamic nuclei provide direct inputs to brain areas involved in affect. Another source is from spinal pathways to somatosensory thalamic and cortical areas and then through a cortico-limbic pathway. The latter integrates nociceptive input with contextual information and memory to provide cognitive mediation of pain affect. Both direct and cortico-limbic pathways converge on the same anterior cingulate cortical and subcortical structures whose function may be to establish emotional valence and response priorities.

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Self-citation

Authors: Price, D. D.
Affiliations: University of Florida (US)
Corresponding author: Price, Donald D.
ORCID: Price, Donald D.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-06-09
Volume: 288
Issue: 5472
Pages: 1769-1772
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.288.5472.1769
OpenAlex: W2007791604
Cited by: 2,092
References: 25
Citations by year: 2026: 50 · 2025: 67 · 2024: 60 · 2023: 77 · 2022: 95 · 2021: 93 · 2020: 88 · 2019: 114 · 2018: 86 · 2017: 88 · 2016: 102 · 2015: 81 · 2014: 79 · 2013: 103 · 2012: 83
FWCI: 26.10
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (R01 295527912)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: affective dimension of pain, pain unpleasantness, nociception, anterior cingulate cortex, medial thalamic nuclei, emotional valence, pain memory
MeSH terms: Affect, Afferent Pathways, Animals, Brain Mapping, Cerebral Cortex, Humans, Limbic System, Pain, Parietal Lobe, Somatosensory Cortex, Spinal Cord, Thalamic Nuclei, Tomography, Emission-Computed

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Psychological and Neural Mechanisms of the Affective Dimension of Pain

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