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A Sequence in M13 Phage Detects Hypervariable Minisatellites in Human and Animal DNA
Open accessAbstract
The term "DNA fingerprint" has been used to describe the extensive restriction fragment length polymorphism associated with hypervariable minisatellites present in the human genome. Until now, it was necessary to hybridize Southern blots to specific probes cloned from human genomic DNA in order to obtain individual-specific restriction patterns. The present study describes the surprising finding that the insert-free, wild-type M13 bacteriophage detects hypervariable minisatellites in human and in animal DNA, provided no competitor DNA is used during hybridization. The effective sequence in M13 was traced to two clusters of 15-base pair repeats within the protein III gene of the bacteriophage. This unexpected use of M13 renders the DNA fingerprinting technology more readily available to molecular biology laboratories.
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Cited by
Weller, J. I., Kashi, Y., & Soller, M. (1990) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(90)78938-2 · Cited by 444
Meyer, W., Mitchell, T. G., Freedman, E. Z., & Vilgalys, R. (1993) · Journal of Clinical Microbiology · doi:10.1128/jcm.31.9.2274-2280.1993 · Cited by 324
Longmire, J. L., Lewis, A. K., Brown, N. C., Buckingham, J. M., Clark, L. M., Jones, M. D., Meincke, L. J., Meyne, J., Ratliff, R. L., Ray, F. A., et al. (1988) · Genomics · doi:10.1016/0888-7543(88)90104-8 · Cited by 301
Perry, R., Heinrichs, C., Bourdoux, P., Khoury, K., Szöts, F., Dussault, J. H., Vassart, G., & Van Vliet, G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011995 · Cited by 167
Self-citationHuys, G., Botteldoorn, N., Delvigne, F., De Vuyst, L., Heyndrickx, M., Pot, B., Dubois, J., & Daube, G. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300065 · Cited by 132
Metadata
- Authors
- Vassart, G., Georges, M., Monsieur, R., Brocas, H., Lequarre, A. S., & Christophe, D.
- Venue
- Science
- Published
- 1987-02-06
- Volume
- 235
- Issue
- 4789
- Pages
- 683-684
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043952976
- Cited by
- 569
- References
- 0
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Vassart, G., Georges, M., Monsieur, R., Brocas, H., Lequarre, A. S., & Christophe, D. (1987). A Sequence in M13 Phage Detects Hypervariable Minisatellites in Human and Animal DNA. Science. https://doi.org/10.1126/science.2880398
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
