The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
A Transgenic Mouse Model for Human Neurofibromatosis
Abstract
Human T-lymphotropic virus type 1 (HTLV-1) has been associated with the neurologic disorder tropical spastic paraparesis and possibly with multiple sclerosis. The tat gene of HTLV-1 under control of its own long terminal repeat is capable of inducing tumors in transgenic mice. The morphologic and biologic properties of these tumors indicate their close resemblance to human neurofibromatosis (von Recklinghausen's disease), the most common single gene disorder to affect the nervous system. The high spontaneous incidence of this disease, together with the diverse clinical and pathologic features associated with it, suggests that environmental factors may account for some of the observed cases. Multiple tumors developed simultaneously in the transgenic tat mice at approximately 3 months of age, and the phenotype was successfully passed through three generations. The tumors arise from the nerve sheaths of peripheral nerves and are composed of perineural cells and fibroblasts. Tumor cells from these mice adapt easily to propagation in culture and continue to express the tat protein in significant amounts. When transplanted into nude mice, these cultured cells efficiently induce tumors. Evidence of HTLV-1 infection in patients with neural and other soft tissue tumors is needed in order to establish a link between infection by this human retrovirus and von Recklinghausen's disease and other nonlymphoid tumors.
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Cites
ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS
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Gene for von Recklinghausen Neurofibromatosis Is in the Pericentromeric Region of Chromosome 17
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Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma
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The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice
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Self-citationGenetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene
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Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene
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Self-citation
Cited by
The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice
Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., & Jay, G. (1988) · Nature · doi:10.1038/335606a0 · Cited by 526
Self-citationThe Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., & Jay, G. (1995) · Nature Genetics · doi:10.1038/ng0195-21 · Cited by 513
Self-citationThe tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice
Nerenberg, M., Hinrichs, S. H., Reynolds, R. K., Khoury, G., & Jay, G. (1987) · Science · doi:10.1126/science.2888190 · Cited by 510
Self-citationJaenisch, R. (1988) · Science · doi:10.1126/science.3287623 · Cited by 485
Molecular genetics of neurofibromatosis type 1 (NF1).
Shen, M. H., Harper, P. S., & Upadhyaya, M. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.1.2 · Cited by 377
Metadata
- Authors
- Hinrichs, S. H., Nerenberg, M., Reynolds, R. K., Khoury, G., & Jay, G.
- Venue
- Science
- Published
- 1987-09-11
- Volume
- 237
- Issue
- 4820
- Pages
- 1340-1343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054778208
- Cited by
- 261
- References
- 25
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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