The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity
Abstract
The fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana , the CLAVATA ( CLV ) genes encode the essential components of a negative, stem cell–restricting pathway. We used transgenic plants overexpressing CLV3 to show that meristem cell accumulation and fate depends directly on the level of CLV3 activity and that CLV3 signaling occurs exclusively through a CLV1/CLV2 receptor kinase complex. We also demonstrate that the CLV pathway acts by repressing the activity of the transcription factor WUSCHEL , an element of the positive, stem cell–promoting pathway.
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Cites
Schoof, H., Lenhard, M., Haecker, A., Mayer, K. F. X., Jürgens, G., & Laux, T. (2000) · Cell · doi:10.1016/s0092-8674(00)80700-x · Cited by 1,749
Role of WUSCHEL in Regulating Stem Cell Fate in the Arabidopsis Shoot Meristem
Mayer, K. F. X., Schoof, H., Haecker, A., Lenhard, M., Jürgens, G., & Laux, T. (1998) · Cell · doi:10.1016/s0092-8674(00)81703-1 · Cited by 1,702
Clark, S. E., Williams, R. W., & Meyerowitz, E. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80239-1 · Cited by 1,373
Self-citationSignaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems
Fletcher, J. C., Brand, U., Running, M. P., Simon, R., & Meyerowitz, E. M. (1999) · Science · doi:10.1126/science.283.5409.1911 · Cited by 1,357
Self-citationSteeves, T. A., & Sussex, I. M. (1989) · doi:10.1017/cbo9780511626227 · Cited by 1,334
The WUSCHEL gene is required for shoot and floral meristem integrity in Arabidopsis
Laux, T., Mayer, K. F. X., Berger, J., & Jürgens, G. (1996) · Development · doi:10.1242/dev.122.1.87 · Cited by 1,268
CLAVATA1, a regulator of meristem and flower development in Arabidopsis
Clark, S. E., Running, M. P., & Meyerowitz, E. M. (1993) · Development · doi:10.1242/dev.119.2.397 · Cited by 876
Self-citationClark, S. E., Running, M. P., & Meyerowitz, E. M. (1995) · Development · doi:10.1242/dev.121.7.2057 · Cited by 729
Self-citationPatterns in Plant Development.
Basile, D. V., Steeves, T. A., & Sussex, I. M. (1974) · Bulletin of the Torrey Botanical Club · doi:10.2307/2484650 · Cited by 663
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Cited by
Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers
Sarkar, A. K., Luijten, M., Miyashima, S., Lenhard, M., Hashimoto, T., Nakajima, K., Scheres, B., Heidstra, R., & Laux, T. (2007) · Nature · doi:10.1038/nature05703 · Cited by 1,120
The Lateral Organ Boundaries Gene Defines a Novel, Plant-Specific Gene Family
Shuai, B., Reynaga-Peña, C. G., & Springer, P. S. (2002) · Plant Physiology · doi:10.1104/pp.010926 · Cited by 555
Williams, L., Grigg, S. P., Xie, M., Christensen, S., & Fletcher, J. C. (2005) · Development · doi:10.1242/dev.01942 · Cited by 448
Self-citationSchrader, J., Nilsson, J., Mellerowicz, E., Berglund, A., Nilsson, P., Hertzberg, M., & Sandberg, G. (2004) · The Plant Cell · doi:10.1105/tpc.104.024190 · Cited by 399
Twenty years on: The inner workings of the shoot apical meristem, a developmental dynamo
Barton, M. K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.029 · Cited by 372
Metadata
- Authors
- Brand, U., Fletcher, J. C., Hobe, M., Meyerowitz, E. M., & Simon, R.
- Venue
- Science
- Published
- 2000-07-28
- Volume
- 289
- Issue
- 5479
- Pages
- 617-619
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989726653
- Cited by
- 1,122
- References
- 21
- FWCI
- 60.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brand, U., Fletcher, J. C., Hobe, M., Meyerowitz, E. M., & Simon, R. (2000). Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity. Science. https://doi.org/10.1126/science.289.5479.617
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
