The Lateral Organ Boundaries Gene Defines a Novel, Plant-Specific Gene Family
Open accessAbstract
The LATERAL ORGAN BOUNDARIES(LOB) gene in Arabidopsis defines a new conserved protein domain. LOB is expressed in a band of cells at the adaxial base of all lateral organs formed from the shoot apical meristem and at the base of lateral roots. LOB encodes a predicted protein that does not have recognizable functional motifs, but that contains a conserved domain (the LOB domain) that is present in 42 other Arabidopsis proteins and in proteins from a variety of other plant species. Proteins showing similarity to the LOB domain were not found outside of plant databases, indicating that this unique protein may play a role in plant-specific processes. Genes encoding LOB domain proteins are expressed in a variety of temporal- and tissue-specific patterns, suggesting that they may function in diverse processes. Loss-of-function LOB mutants have no detectable phenotype under standard growth conditions, suggesting thatLOB is functionally redundant or required during growth under specific environmental conditions. Ectopic expression ofLOB leads to alterations in the size and shape of leaves and floral organs and causes male and female sterility. The expression of LOB at the base of lateral organs suggests a potential role for LOB in lateral organ development.
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The pattern of LAS transcript accumulation in the axils of leaf primordia is similar to those of LOB, CUC1, and CUC2.
“The pattern of LAS transcript accumulation in the axils of leaf primordia is similar to those of the genes LATERAL ORGAN BOUNDARIES ( LOB ), CUPSHAPED COTYLEDON1 ( CUC1 ), and CUP-SHAPED COTYLEDON2 ( CUC2 ).”
From Molecular analysis of the <i>LATERAL SUPPRESSOR</i> gene in <i>Arabidopsis</i> reveals a conserved control mechanism for axillary meristem formation (2003) · cites this paper as Shuai et al. 2002
Transcripts of LOB, CUC1, and CUC2 are detected at the boundary of the SAM and the new leaf primordium.
“Transcripts of all these genes are detected at the boundary of two tissues, the SAM and the new leaf primordium (Aida et al. 1999; Takada et al. 2001; Shuai et al. 2002).”
From Molecular analysis of the <i>LATERAL SUPPRESSOR</i> gene in <i>Arabidopsis</i> reveals a conserved control mechanism for axillary meristem formation (2003) · cites this paper as Shuai et al. 2002
LOB is expressed in the boundaries between meristems and lateral organs.
“The founding member of the LBD family, LATERAL ORGAN BOUNDARIES (LOB), was identified as an enhancer trap line showing expression in the boundaries between meristems and lateral organs (Shuai et al., 2002).”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Shuai et al., 2002
Loss-of-function mutants of LOB show fusion of axillary branch and leaf.
“| LOB | ra2 (maize (Zea mays)) | LBD | Fusion of axillary branch and | SAM and lateral organs | Shuai et al. (2002); Zhou et al. |”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Shuai et al. (2002)
LOB is expressed in the boundary between the SAM and lateral organs.
“| LOB | ra2 (maize (Zea mays)) | LBD | Fusion of axillary branch and | SAM and lateral organs | Shuai et al. (2002); Zhou et al. |”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Shuai et al. (2002)
The Arabidopsis LOB gene encodes an LBD protein family protein.
“| LOB | ra2 (maize (Zea mays)) | LBD | Fusion of axillary branch and | SAM and lateral organs | Shuai et al. (2002); Zhou et al. |”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Shuai et al. (2002)
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“Transcripts of all these genes are detected at the boundary of two tissues, the SAM and the new leaf primordium (Aida et al. 1999; Takada et al. 2001; Shuai et al. 2002).”
BackgroundRoot system architecture: insights from <i>Arabidopsis</i> and cereal crops
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Auxin-related gene families in abiotic stress response in Sorghum bicolor
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<i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems
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- Authors
- Shuai, B., Reynaga-Peña, C. G., & Springer, P. S.
- Affiliations
- University of California, Riverside (US)
- Department of Botany and Plant Sciences, University of California, Riverside, California, 92521–0124
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06-01
- Volume
- 129
- Issue
- 2
- Pages
- 747-761
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- PMC
- PMC161698
- OpenAlex
- W2113355569
- Cited by
- 555
- References
- 2
- Citations by year
- 2026: 24 · 2025: 37 · 2024: 39 · 2023: 28 · 2022: 26 · 2021: 31 · 2020: 19 · 2019: 15 · 2018: 21 · 2017: 31 · 2016: 24 · 2015: 19 · 2014: 19 · 2013: 24 · 2012: 33
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- PLANT PHYSIOLOGY (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Holmes Museum Of Anthropology (Wichita State University) (submittedVersion)
- Funders
- National Science Foundation (9875371)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Keywords
- conserved domains, gene family, lateral organ development, lateral roots, shoot apical meristem, leaf shape, floral organ development, male sterility, female sterility, functional redundancy, Arabidopsis thaliana
- MeSH terms
- Amino Acid Sequence, DNA Transposable Elements, Multigene Family, Glucuronidase, Molecular Sequence Data, Mutation, Phenotype, Recombinant Fusion Proteins, Sequence Alignment, Arabidopsis, Sequence Homology, Amino Acid, Alternative Splicing, Sequence Analysis, DNA, DNA, Complementary, Gene Expression Regulation, Plant, Gene Expression Regulation, Developmental, Plant Roots, Plant Shoots, Arabidopsis Proteins, Plants, Genetically Modified
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