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Signal Transduction Through Prion Protein
Abstract
The cellular prion protein PrP c is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrP c -dependent signal transduction through antibody-mediated cross-linking. A caveolin-1–dependent coupling of PrP c to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrP c -dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrP c occurred mainly at neurites. Thus, PrP c may be a signal transduction protein.
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Citations
Cited by
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989
The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870
Normal huntingtin function: an alternative approach to Huntington's disease
Cattaneo, E., Zuccato, C., & Tartari, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1806 · Cited by 657
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Santuccione, A., Sytnyk, V., Leshchyns'ka, I., & Schachner, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200409127 · Cited by 419
Metadata
- Authors
- Mouillet-Richard, S., Ermonval, M., Chebassier, C., Laplanche, J. L., Lehmann, S., Launay, J. M., & Kellermann, O.
- Venue
- Science
- Published
- 2000-09-15
- Volume
- 289
- Issue
- 5486
- Pages
- 1925-1928
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080514032
- Cited by
- 805
- References
- 0
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mouillet-Richard, S., Ermonval, M., Chebassier, C., Laplanche, J. L., Lehmann, S., Launay, J. M., & Kellermann, O. (2000). Signal Transduction Through Prion Protein. Science. https://doi.org/10.1126/science.289.5486.1925
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
