The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth
Open accessAbstract
In spite of advances in understanding the role of the cellular prion protein (PrP) in neural cell interactions, the mechanisms of PrP function remain poorly characterized. We show that PrP interacts directly with the neural cell adhesion molecule (NCAM) and associates with NCAM at the neuronal cell surface. Both cis and trans interactions between NCAM at the neuronal surface and PrP promote recruitment of NCAM to lipid rafts and thereby regulate activation of fyn kinase, an enzyme involved in NCAM-mediated signaling. Cis and trans interactions between NCAM and PrP promote neurite outgrowth. When these interactions are disrupted in NCAM-deficient and PrP-deficient neurons or by PrP antibodies, NCAM/PrP-dependent neurite outgrowth is arrested, indicating that PrP is involved in nervous system development cooperating with NCAM as a signaling receptor.
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Cites
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Büeler, H., Fischer, M., Lang, Y., Bluethmann, H., Lipp, H.-P., DeArmond, S. J., Prusiner, S. B., Aguet, M., & Weissmann, C. (1992) · Nature · doi:10.1038/356577a0 · Cited by 1,655
Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components
Harder, T., Scheiffele, P., Verkade, P., & Simons, K. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.929 · Cited by 1,184
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
Grant, S. G. N., O'Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1361685 · Cited by 1,155
Cremer, H., Lange, R., Christoph, A., Plomann, M., Vopper, G., Roes, J., Brown, R., Baldwin, S., Kraemer, P., Scheff, S., et al. (1994) · Nature · doi:10.1038/367455a0 · Cited by 1,007
Telling, G. C., Scott, M., Mastrianni, J., Gabizon, R., Torchia, M., Cohen, F. E., DeArmond, S. J., & Prusiner, S. B. (1995) · Cell · doi:10.1016/0092-8674(95)90236-8 · Cited by 857
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
Hsiao, K., Baker, H. F., Crow, T. J., Poulter, M., Owen, F., Terwilliger, J. D., Westaway, D., Ott, J., & Prusiner, S. B. (1989) · Nature · doi:10.1038/338342a0 · Cited by 849
Signal Transduction Through Prion Protein
Mouillet-Richard, S., Ermonval, M., Chebassier, C., Laplanche, J. L., Lehmann, S., Launay, J. M., & Kellermann, O. (2000) · Science · doi:10.1126/science.289.5486.1925 · Cited by 805
Prion protein is necessary for normal synaptic function
Collinge, J., Whittington, M. A., Sidle, K. C. L., Smith, C. J., Palmer, M. S., Clarke, A. R., & Jefferys, J. G. R. (1994) · Nature · doi:10.1038/370295a0 · Cited by 799
Rathjen, F. G., & Schachner, M. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01753.x · Cited by 741
Self-citation
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Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930
Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis
Viola, K. L., & Klein, W. L. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1386-3 · Cited by 628
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein
Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Colombo, L., Manzoni, C., Borsello, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911829107 · Cited by 466
Chin, J., Palop, J. J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., & Mucke, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-05.2005 · Cited by 312
Metadata
- Authors
- Santuccione, A., Sytnyk, V., Leshchyns'ka, I., & Schachner, M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-04-25
- Volume
- 169
- Issue
- 2
- Pages
- 341-354
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1985630952
- Cited by
- 419
- References
- 47
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Santuccione, A., Sytnyk, V., Leshchyns'ka, I., & Schachner, M. (2005). Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200409127
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