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A Niche Maintaining Germ Line Stem Cells in the Drosophila Ovary
Abstract
Stromal cells are thought to generate specific regulatory microenviroments or “niches” that control stem cell behavior. Characterizing stem cell niches in vivo remains an important goal that has been difficult to achieve. The individual ovarioles of the Drosophila ovary each contain about two germ line stem cells that maintain oocyte production. Here we show that anterior ovariolar somatic cells comprising three cell types act as a germ line stem cell niche. Germ line stem cells lost by normal or induced differentiation are efficiently replaced, and the ability to repopulate the niche increases the functional lifetime of ovarioles in vivo. Our studies implicate one of the somatic cell types, the cap cells, as a key niche component.
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Cited by
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2269 · Cited by 851
Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B., & Fuller, M. T. (2001) · Science · doi:10.1126/science.1066707 · Cited by 698
Stem cells, ageing and the quest for immortality
Rando, T. A. (2006) · Nature · doi:10.1038/nature04958 · Cited by 695
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0538 · Cited by 611
Metadata
- Authors
- Xie, T., & Spradling, A. C.
- Venue
- Science
- Published
- 2000-10-13
- Volume
- 290
- Issue
- 5490
- Pages
- 328-330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1600103888
- Cited by
- 777
- References
- 0
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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