Stem cells, ageing and the quest for immortality
Abstract
Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.
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Long-lived non-dividing quiescent stem cells may accumulate damage from environmental stress, similar to other long-lived cells.
“Long-lived, non-dividing quiescent stem cells may accumulate damage from environmental stress (for example, oxidative stress caused by the accumulation of reactive oxygen species (ROS)), similarly to any long-lived cell such as a post-mitotic neuron or cardio-myocyte103.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [103]
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Pekovic, V., & Hutchison, C. J. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00928.x · Cited by 75 · see citing works
Geroconversion of aged muscle stem cells under regenerative pressure
Sousa-Victor, P., Perdiguero, E., & Muñoz-Cánoves, P. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965072 · Cited by 68 · see citing works
Mehdi, M. M., Solanki, P., & Singh, P. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104413 · Cited by 54 · see citing works
Stem cell ageing and non-random chromosome segregation
Charville, G. W., & Rando, T. A. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0279 · Cited by 45 · see citing works
Self-citationMuscle regeneration is undisturbed by repeated polytraumatic injury
Horváthy, D. B., Nardai, P. P., Major, T., Schandl, K., Cselenyák, A., Vácz, G., Kiss, L., Szendrői, M., & Lacza, Z. (2011) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-010-0034-9 · Cited by 5 · see citing works
- Authors
- Rando, T. A.
- Affiliations
- VA Palo Alto Health Care System (US)
- Corresponding author
- Rando, Thomas A.
- ORCID
- Rando, Thomas A.
- Venue
- Nature
- Published
- 2006-06
- Volume
- 441
- Issue
- 7097
- Pages
- 1080-1086
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2066630518
- Cited by
- 695
- References
- 68
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 21 · 2023: 18 · 2022: 20 · 2021: 34 · 2020: 20 · 2019: 32 · 2018: 38 · 2017: 43 · 2016: 41 · 2015: 43 · 2014: 48 · 2013: 51 · 2012: 48
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- adult stem cells, aging, stem cell aging, tissue regeneration, regenerative medicine, tissue homeostasis, degenerative diseases, tissue damage, stem cell therapy
- MeSH terms
- Aging, Animals, Biological Evolution, Germ Cells, Humans, Longevity, Stem Cells, Regenerative Medicine
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