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Direct Coupling Between Meiotic DNA Replication and Recombination Initiation
Abstract
During meiosis in Saccharomyces cerevisiae , DNA replication occurs 1.5 to 2 hours before recombination initiates by DNA double-strand break formation. We show that replication and recombination initiation are directly linked. Blocking meiotic replication prevented double-strand break formation in a replication-checkpoint–independent manner, and delaying replication of a chromosome segment specifically delayed break formation in that segment. Consequently, the time between replication and break formation was held constant in all regions. We suggest that double-strand break formation occurs as part of a process initiated by DNA replication, which thus determines when meiotic recombination initiates on a regional rather than a cell-wide basis.
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Citations
Cited by
Cell Cycle Regulation of DNA Replication
Sclafani, R. A., & Holzen, T. M. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130308 · Cited by 450
A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex
Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384
Panizza, S., Mendoza, M. A., Berlinger, M., Huang, L., Nicolas, A., Shirahige, K., & Klein, F. (2011) · Cell · doi:10.1016/j.cell.2011.07.003 · Cited by 366
Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis
Keeney, S. (2007) · Genome Dynamics and Stability · doi:10.1007/7050_2007_026 · Cited by 330
Yelina, N. E., Lambing, C., Hardcastle, T. J., Zhao, X., Santos, B., & Henderson, I. R. (2015) · Genes & Development · doi:10.1101/gad.270876.115 · Cited by 198
Metadata
- Authors
- Borde, V., Goldman, A. S. H., & Lichten, M.
- Venue
- Science
- Published
- 2000-10-27
- Volume
- 290
- Issue
- 5492
- Pages
- 806-809
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976561295
- Cited by
- 243
- References
- 0
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Borde, V., Goldman, A. S. H., & Lichten, M. (2000). Direct Coupling Between Meiotic DNA Replication and Recombination Initiation. Science. https://doi.org/10.1126/science.290.5492.806
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