The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane
Abstract
Evidence for a new signaling mechanism consisting of ligand-independent lateral propagation of receptor activation in the plasma membrane is presented. We visualized the phosphorylation of green fluorescent protein (GFP)–tagged ErbB1 (ErbB1-GFP) receptors in cells focally stimulated with epidermal growth factor (EGF) covalently attached to beads. This was achieved by quantitative imaging of protein reaction states in cells by fluorescence resonance energy transfer (FRET) with global analysis of fluorescence lifetime imaging microscopy (FLIM) data. The rapid and extensive propagation of receptor phosphorylation over the entire cell after focal stimulation demonstrates a signaling wave at the plasma membrane resulting in full activation of all receptors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Epidermal growth factor-related peptides and their receptors in human malignancies
Salomon, D. S., Brandt, R., Ciardiello, F., & Normanno, N. (1995) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(94)00144-i · Cited by 2,690
Theoretical analysis of fluorescence photobleaching recovery experiments
Soumpasis, D. M. (1983) · Biophysical Journal · doi:10.1016/s0006-3495(83)84410-5 · Cited by 754
Fluorescence lifetime imaging microscopy: spatial resolution of biochemical processes in the cell
Bastiaens, P. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01410-x · Cited by 716
Self-citationAlroy, I., & Yarden, Y. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00412-2 · Cited by 714
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
Guy, P. M., Platko, J. V., Cantley, L. C., Cerione, R. A., & Carraway, K. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8132 · Cited by 698
Yarden, Y., & Schlessinger, J. (1987) · Biochemistry · doi:10.1021/bi00379a035 · Cited by 627
Yarden, Y., & Schlessinger, J. (1987) · Biochemistry · doi:10.1021/bi00379a034 · Cited by 507
An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins
Kavanaugh, W. M., & Williams, L. T. (1994) · Science · doi:10.1126/science.7527937 · Cited by 501
[2] Global analysis of biochemical and biophysical data
Beechem, J. M. (1992) · Methods in Enzymology · doi:10.1016/0076-6879(92)10004-w · Cited by 378
Gadella, T. W. J., Jovin, T. M., & Clegg, R. M. (1993) · Biophysical Chemistry · doi:10.1016/0301-4622(93)85012-7 · Cited by 375
Cited by
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Li, S., Schmitz, K. R., Jeffrey, P. D., Wiltzius, J. J. W., Kussie, P., & Ferguson, K. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.003 · Cited by 1,118
Heterodimerization and Endocytosis of Arabidopsis Brassinosteroid Receptors BRI1 and AtSERK3 (BAK1)
Russinova, E., Borst, J.-W., Kwaaitaal, M., Caño-Delgado, A., Yin, Y., Chory, J., & de Vries, S. C. (2004) · The Plant Cell · doi:10.1105/tpc.104.025387 · Cited by 478
Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum
Haj, F. G., Verveer, P. J., Squire, A., Neel, B. G., & Bastiaens, P. I. H. (2002) · Science · doi:10.1126/science.1067566 · Cited by 434
Self-citationGiordano, L., Jovin, T. M., Irie, M., & Jares-Erijman, E. A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016969k · Cited by 400
Metadata
- Authors
- Verveer, P. J., Wouters, F. S., Reynolds, A. R., & Bastiaens, P. I. H.
- Venue
- Science
- Published
- 2000-11-24
- Volume
- 290
- Issue
- 5496
- Pages
- 1567-1570
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070782703
- Cited by
- 351
- References
- 28
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane. https://app.cochat.ai/papers/10.1126/science.290.5496.1567
- The paper
- Verveer, P. J., Wouters, F. S., Reynolds, A. R., & Bastiaens, P. I. H. (2000). Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane. Science. https://doi.org/10.1126/science.290.5496.1567
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
