The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions
Open accessAbstract
Ligand‐induced activation of receptor tyrosine kinases (RTK) results in the initiation of diverse cellular pathways, including proliferation, differentiation and cell migration. The ErbB family of RTKs represents a model for signal diversification through the formation of homo‐ and heterodimeric receptor complexes. Each dimeric receptor complex will initiate a distinct signaling pathway by recruiting a different set of Src homology 2‐ (SH2‐) containing effector proteins. Further complexity is added due to the existence of an oncogenic receptor that enhances and stabilizes dimerization but has no ligand (ErbB‐2), and a receptor that can recruit novel SH‐2‐containing proteins, but is itself devoid of kinase activity (ErbB‐3). The resulting signaling network has important implications for embryonic development and malignant transformation.
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Cites
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
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Yarden, Y., & Schlessinger, J. (1987) · Biochemistry · doi:10.1021/bi00379a035 · Cited by 627
Self-citationIsobe, T., Okuyama, T., Toyoda, H., Komurasaki, T., Uchida, D., Takayama, Y., & Hanada, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7495 · Cited by 269
Cited by
Direct observation of individual endogenous protein complexes in situ by proximity ligation
Söderberg, O., Gullberg, M., Jarvius, M., Ridderstråle, K., Leuchowius, K.-J., Jarvius, J., Wester, K., Hydbring, P., Bahram, F., Larsson, L.-G., et al. (2006) · Nature Methods · doi:10.1038/nmeth947 · Cited by 2,419
Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer
Mendelsohn, J., & Baselga, J. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.01.504 · Cited by 1,255
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J., & Brugge, J. S. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-785 · Cited by 554
Regulation of neurogenesis by growth factors and neurotransmitters
Cameron, H. A., Hazel, T. G., & McKay, R. D. G. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2<287::aid-neu13>3.0.co;2-b · Cited by 494
Epidermal growth factor receptor inhibition strategies in oncology
Harari, P. M. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00600 · Cited by 423
Metadata
- Authors
- Alroy, I., & Yarden, Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-06-23
- Volume
- 410
- Issue
- 1
- Pages
- 83-86
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2058586542
- Cited by
- 714
- References
- 4
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Alroy, I., & Yarden, Y. (1997). The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)00412-2
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