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Migration of Plasmodium Sporozoites Through Cells Before Infection
Abstract
Intracellular bacteria and parasites typically invade host cells through the formation of an internalization vacuole around the invading pathogen. Plasmodium sporozoites, the infective stage of the malaria parasite transmitted by mosquitoes, have an alternative mechanism to enter cells. We observed breaching of the plasma membrane of the host cell followed by rapid repair. This mode of entry did not result in the formation of a vacuole around the sporozoite, and was followed by exit of the parasite from the host cell. Sporozoites traversed the cytosol of several cells before invading a hepatocyte by formation of a parasitophorous vacuole, in which they developed into the next infective stage. Sporozoite migration through several cells in the mammalian host appears to be essential for the completion of the life cycle.
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Citations
Cited by
The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
Arun Kumar, K., Sano, G.-I., Boscardin, S., Nussenzweig, R. S., Nussenzweig, M. C., Zavala, F., & Nussenzweig, V. (2006) · Nature · doi:10.1038/nature05361 · Cited by 254
Self-citationInnate inflammatory response to the malarial pigment hemozoin
Shio, M. T., Kassa, F. A., Bellemare, M.-J., & Olivier, M. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.07.001 · Cited by 96
Tissue tropism in parasitic diseases
Silva Pereira, S., Trindade, S., De Niz, M., & Figueiredo, L. M. (2019) · Open Biology · doi:10.1098/rsob.190036 · Cited by 85
Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner
Saliba, K. J., & Kirk, K. (2001) · International Journal for Parasitology · doi:10.1016/s0020-7519(01)00258-2 · Cited by 68
Metadata
- Authors
- Mota, M. M., Pradel, G., Vanderberg, J. P., Hafalla, J. C. R., Frevert, U., Nussenzweig, R. S., Nussenzweig, V., & Rodrı́guez, A.
- Venue
- Science
- Published
- 2001-01-05
- Volume
- 291
- Issue
- 5501
- Pages
- 141-144
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021528981
- Cited by
- 542
- References
- 0
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mota, M. M., Pradel, G., Vanderberg, J. P., Hafalla, J. C. R., Frevert, U., Nussenzweig, R. S., Nussenzweig, V., & Rodrı́guez, A. (2001). Migration of Plasmodium Sporozoites Through Cells Before Infection. Science. https://doi.org/10.1126/science.291.5501.141
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