The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster
Abstract
The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate the absence of glutathione reductase in Drosophila melanogaster , identify a new type of thioredoxin reductase, and provide evidence that a thioredoxin system supports GSSG reduction. Our data suggest that antioxidant defense in Drosophila , and probably in related insects, differs fundamentally from that in other organisms.
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Cites
The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S. E., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,929
MUSTACICH, D., & POWIS, G. (2000) · Biochemical Journal · doi:10.1042/bj3460001 · Cited by 592
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Human Placenta Thioredoxin Reductase
Gromer, S., Arscott, L. D., Williams, C. H., Schirmer, R. H., & Becker, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20096 · Cited by 536
Self-citationZhong, L., Arnér, E. S. J., & Holmgren, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100114897 · Cited by 527
Zhong, L., & Holmgren, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000690200 · Cited by 427
Thioredoxin reductase as a pathophysiological factor and drug target
Becker, K., Gromer, S., Schirmer, R. H., & Müller, S. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01703.x · Cited by 388
Self-citationThioredoxin reductase: Two modes of catalysis have evolved
Williams, C. H., Arscott, L. D., Müller, S., Lennon, B. W., Ludwig, M. L., Wang, P., Veine, D. M., Becker, K., & Schirmer, R. H. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01702.x · Cited by 343
Self-citationPreparation and assay of mammalian thioredoxin and thioredoxin reductase
Arnér, E. S. J., Zhong, L., & Holmgren, A. (1999) · Methods in Enzymology · doi:10.1016/s0076-6879(99)00129-9 · Cited by 322
The Thioredoxin System of the Malaria Parasite Plasmodium falciparum
Kanzok, S. M., Schirmer, R. H., Türbachova, I., Iozef, R., & Becker, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007633200 · Cited by 251
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Cited by
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
Reich, H. J., & Hondal, R. J. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00031 · Cited by 923
Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
Zdobnov, E. M., von Mering, C., Letunic, I., Torrents, D., Suyama, M., Copley, R. R., Christophides, G. K., Thomasova, D., Holt, R. A., Subramanian, G. M., et al. (2002) · Science · doi:10.1126/science.1077061 · Cited by 553
Meyer, Y., Belin, C., Delorme-Hinoux, V., Reichheld, J.-P., & Riondet, C. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4327 · Cited by 406
Schulze, P. C., Yoshioka, J., Takahashi, T., He, Z., King, G. L., & Lee, R. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400549200 · Cited by 369
Metadata
- Authors
- Kanzok, S. M., Fechner, A., Bauer, H., Ulschmid, J. K., Müller, H.-M., Botella-Munoz, J., Schneuwly, S., Schirmer, R. H., & Becker, K.
- Venue
- Science
- Published
- 2001-01-26
- Volume
- 291
- Issue
- 5504
- Pages
- 643-646
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043825211
- Cited by
- 406
- References
- 15
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kanzok, S. M., Fechner, A., Bauer, H., Ulschmid, J. K., Müller, H.-M., Botella-Munoz, J., Schneuwly, S., Schirmer, R. H., & Becker, K. (2001). Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster. Science. https://doi.org/10.1126/science.291.5504.643
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