The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Control of Fusion Pore Dynamics During Exocytosis by Munc18
Abstract
Intracellular membrane fusion is mediated by the SNARE (soluble N -ethylmaleimide–sensitive factor attachment protein receptor) proteins. All vesicle transport steps also have an essential requirement for a member of the Sec1 protein family, including the neuronal Munc18-1 (also known as nSec1) in regulated exocytosis. Here, in adrenal chromaffin cells, we expressed a Munc18 mutant with reduced affinity for syntaxin, which specifically modified the kinetics of single-granule exocytotic release events, consistent with an acceleration of fusion pore expansion. Thus, Munc18 functions in a late stage in the fusion process, where its dissociation from syntaxin determines the kinetics of postfusion events.
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Citations
Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Cited by
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Self-citationSelective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
Shen, J., Tareste, D. C., Paumet, F., Rothman, J. E., & Melia, T. J. (2007) · Cell · doi:10.1016/j.cell.2006.12.016 · Cited by 484
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Munc18-1 Promotes Large Dense-Core Vesicle Docking
Voets, T., Toonen, R. F., Brian, E. C., de Wit, H., Moser, T., Rettig, J., Südhof, T. C., Neher, E., & Verhage, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00391-9 · Cited by 396
Metadata
- Authors
- Fisher, R. J., Pevsner, J., & Burgoyne, R. D.
- Venue
- Science
- Published
- 2001-02-02
- Volume
- 291
- Issue
- 5505
- Pages
- 875-878
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011814301
- Cited by
- 195
- References
- 1
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fisher, R. J., Pevsner, J., & Burgoyne, R. D. (2001). Control of Fusion Pore Dynamics During Exocytosis by Munc18. Science. https://doi.org/10.1126/science.291.5505.875
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
