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Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver
Abstract
DNA and nuclear proteins were transferred into cells simultaneously at more than 95% efficiency by means of vesicle complexes. The DNA was rapidly transported into the nuclei of cultured cells, and its expression reached a maximum within 6 to 8 hours after its introduction. Moreover, when the plasmid DNA and nuclear protein were cointroduced into nondividing cells in rat liver by injection into the portal veins of adult rats, the plasmid DNA was carried into liver cell nuclei efficiently by nuclear protein. The expression of the DNA in adult rat liver, on introduction of the DNA with nuclear protein, was more than five times as great as with nonnuclear protein.
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Cited by
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
DNA Vaccines: Immunology, Application, and Optimization
Gurunathan, S., Klinman, D. M., & Seder, R. A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.927 · Cited by 1,207
Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
Merdan, T., Kopec̆ek, J., & Kissel, T. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00046-7 · Cited by 785
In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.
Yang, N. S., Burkholder, J., Roberts, B., Martinell, B., & McCabe, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9568 · Cited by 600
Hepatocyte growth factor gene therapy of liver cirrhosis in rats
Ueki, T., Kaneda, Y., Tsutsui, H., Nakanishi, K., Sawa, Y., Morishita, R., Matsumoto, K., Nakamura, T., Takahashi, H., Okamoto, E., et al. (1999) · Nature Medicine · doi:10.1038/5593 · Cited by 587
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Metadata
- Authors
- Kaneda, Y., Iwai, K., & Uchida, T.
- Venue
- Science
- Published
- 1989-01-20
- Volume
- 243
- Issue
- 4889
- Pages
- 375-378
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168837119
- Cited by
- 454
- References
- 0
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaneda, Y., Iwai, K., & Uchida, T. (1989). Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver. Science. https://doi.org/10.1126/science.2911748
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
