The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
DNA Vaccines: Immunology, Application, and Optimization
Abstract
The development and widespread use of vaccines against infectious agents have been a great triumph of medical science. One reason for the success of currently available vaccines is that they are capable of inducing long-lived antibody responses, which are the principal agents of immune protection against most viruses and bacteria. Despite these successes, vaccination against intracellular organisms that require cell-mediated immunity, such as the agents of tuberculosis, malaria, leishmaniasis, and human immunodeficiency virus infection, are either not available or not uniformly effective. Owing to the substantial morbidity and mortality associated with these diseases worldwide, an understanding of the mechanisms involved in generating long-lived cellular immune responses has tremendous practical importance. For these reasons, a new form of vaccination, using DNA that contains the gene for the antigen of interest, is under intensive investigation, because it can engender both humoral and cellular immune responses. This review focuses on the mechanisms by which DNA vaccines elicit immune responses. In addition, a list of potential applications in a variety of preclinical models is provided.
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Cites
Direct Gene Transfer into Mouse Muscle in Vivo
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CpG motifs in bacterial DNA trigger direct B-cell activation
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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
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Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
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Self-citation
Cited by
Fleeton, M. N., Chen, M., Berglund, P., Rhodes, G., Parker, S. E., Murphy, M., Atkins, G. J., & Liljeström, P. (2001) · The Journal of Infectious Diseases · doi:10.1086/319857 · Cited by 157
Feng, G., Jiang, Q., Xia, M., Lu, Y., Qiu, W., Zhao, D., Lu, L., Peng, G., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061135 · Cited by 108
RetractedAged murine hematopoietic stem cells drive aging-associated immune remodeling
Leins, H., Mulaw, M., Eiwen, K., Sakk, V., Liang, Y., Denkinger, M., Geiger, H., & Schirmbeck, R. (2018) · Blood · doi:10.1182/blood-2018-02-831065 · Cited by 95
Samsa, M. M., Dupuy, L. C., Beard, C. W., Six, C. M., Schmaljohn, C. S., Mason, P. W., Geall, A. J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.12.013 · Cited by 63
Kim, H., Seo, E.-H., Lee, S.-H., & Kim, B.-J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122054 · Cited by 48
Metadata
- Authors
- Gurunathan, S., Klinman, D. M., & Seder, R. A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 18
- Issue
- 1
- Pages
- 927-974
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2109352986
- Cited by
- 1,207
- References
- 180
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gurunathan, S., Klinman, D. M., & Seder, R. A. (2000). DNA Vaccines: Immunology, Application, and Optimization. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.18.1.927
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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