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Impact of Polymer Tether Length on Multiple Ligand-Receptor Bond Formation
Abstract
The promoters of cell adhesion are ligands, which are often attached to flexible tethers that bind to surface receptors on adjacent cells. Using a combination of Monte Carlo simulations, diffusion reaction theory, and direct experiments (surface force measurements) of the biotin-streptavidin system, we have quantified polymer chain dynamics and the kinetics and spatial range of tethered ligand-receptor binding. The results show that the efficiency of strong binding does not depend solely on the molecular architecture or binding energy of the receptor-ligand pair, nor on the equilibrium configuration of the polymer tether, but rather on its “rare” extended conformations.
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Citations
Cited by
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Toy, R., Peiris, P. M., Ghaghada, K. B., & Karathanasis, E. (2014) · Nanomedicine · doi:10.2217/nnm.13.191 · Cited by 570
Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis
Almutairi, A., Rossin, R., Shokeen, M., Hagooly, A., Ananth, A., Capoccia, B., Guillaudeu, S., Abendschein, D., Anderson, C. J., Welch, M. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811757106 · Cited by 235
Targeted binding of PLA microparticles with lipid-PEG-tethered ligands
Duncanson, W. J., Figa, M. A., Hallock, K., Zalipsky, S., Hamilton, J. A., & Wong, J. Y. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.05.044 · Cited by 75
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Metadata
- Authors
- Jeppesen, C., Wong, J. Y., Kuhl, T. L., Israelachvili, J. N., Mullah, N., Zalipsky, S., & Marques, C. M.
- Venue
- Science
- Published
- 2001-07-20
- Volume
- 293
- Issue
- 5529
- Pages
- 465-468
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974872356
- Cited by
- 231
- References
- 0
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jeppesen, C., Wong, J. Y., Kuhl, T. L., Israelachvili, J. N., Mullah, N., Zalipsky, S., & Marques, C. M. (2001). Impact of Polymer Tether Length on Multiple Ligand-Receptor Bond Formation. Science. https://doi.org/10.1126/science.293.5529.465
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
