The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish
Abstract
Cardiac valve formation is a complex process that involves cell signaling events between the myocardial and endocardial layers of the heart across an elaborate extracellular matrix. These signals lead to marked morphogenetic movements and transdifferentiation of the endocardial cells at chamber boundaries. Here we identify the genetic defect in zebrafish jekyll mutants, which are deficient in the initiation of heart valve formation. The jekyll mutation disrupts a homolog of Drosophila Sugarless, a uridine 5′-diphosphate (UDP)–glucose dehydrogenase required for heparan sulfate, chondroitin sulfate, and hyaluronic acid production. The atrioventricular border cells do not differentiate from their neighbors in jekyll mutants, suggesting that Jekyll is required in a cell signaling event that establishes a boundary between the atrium and ventricle.
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Multiple essential functions of neuregulin in development
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Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
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Cited by
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495
Heart Valve Development: Regulatory Networks in Development and Disease
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Has2 expression in heart forming regions is independent of BMP signaling
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Metadata
- Authors
- Walsh, E. C., & Stainier, D. Y. R.
- Venue
- Science
- Published
- 2001-08-31
- Volume
- 293
- Issue
- 5535
- Pages
- 1670-1673
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969670626
- Cited by
- 289
- References
- 31
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Walsh, E. C., & Stainier, D. Y. R. (2001). UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish. Science. https://doi.org/10.1126/science.293.5535.1670
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
