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A Blood Vessel Model Constructed from Collagen and Cultured Vascular Cells
Abstract
A model of a blood vessel was constructed in vitro. Its multilayered structure resembled that of an artery and it withstood physiological pressures. Electron microscopy showed that the endothelial cells lining the lumen and the smooth muscle cells in the wall were healthy and well differentiated. The lining of endothelial cells functioned physically, as a permeability barrier, and biosynthetically, producing von Willebrand's factor and prostacyclin. The strength of the model depended on its multiple layers of collagen integrated with a Dacron mesh.
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Cited by
Functional Arteries Grown in Vitro
Niklason, L. E., Gao, J., Abbott, W. M., Hirschi, K. K., Houser, S., Marini, R., & Langer, R. (1999) · Science · doi:10.1126/science.284.5413.489 · Cited by 1,766
Human tissue-engineered blood vessels for adult arterial revascularization
L'Heureux, N., Dusserre, N., Konig, G., Victor, B., Keire, P., Wight, T. N., Chronos, N. A. F., Kyles, A. E., Gregory, C. R., Hoyt, G., et al. (2006) · Nature Medicine · doi:10.1038/nm1364 · Cited by 1,083
Dynamic Mechanical Conditioning of Collagen-Gel Blood Vessel Constructs Induces Remodeling In Vitro
Seliktar, D., Black, R. A., Vito, R. P., & Nerem, R. M. (2000) · Annals of Biomedical Engineering · doi:10.1114/1.275 · Cited by 555
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Song, H.-H. G., Rumma, R. T., Ozaki, C. K., Edelman, E. R., & Chen, C. S. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.009 · Cited by 476
Nerem, R. M., & Seliktar, D. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.225 · Cited by 466
Metadata
- Authors
- Weinberg, C. B., & Bell, E.
- Venue
- Science
- Published
- 1986-01-24
- Volume
- 231
- Issue
- 4736
- Pages
- 397-400
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989704675
- Cited by
- 1,240
- References
- 0
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weinberg, C. B., & Bell, E. (1986). A Blood Vessel Model Constructed from Collagen and Cultured Vascular Cells. Science. https://doi.org/10.1126/science.2934816
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
