The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Functional Arteries Grown in Vitro
Abstract
A tissue engineering approach was developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue. Bovine vessels cultured under pulsatile conditions had rupture strengths greater than 2000 millimeters of mercury, suture retention strengths of up to 90 grams, and collagen contents of up to 50 percent. Cultured vessels also showed contractile responses to pharmacological agents and contained smooth muscle cells that displayed markers of differentiation such as calponin and myosin heavy chains. Tissue-engineered arteries were implanted in miniature swine, with patency documented up to 24 days by digital angiography.
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Citations
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,630
Woessner, J. F. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90291-0 · Cited by 3,840
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Regulation of differentiation of vascular smooth muscle cells
Owens, G. K. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.487 · Cited by 1,721
Ross, R. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.50.1.172 · Cited by 1,569
Risau, W., & Flamme, I. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000445 · Cited by 1,406
A completely biological tissue-engineered human blood vessel
L'heureux, N., Pâquet, S., Labbé, R., Germain, L., & Auger, F. A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.47 · Cited by 1,402
Fluorometric assay of DNA in cartilage explants using Hoechst 33258
Kim, Y.-J., Sah, R. L. Y., Doong, J.-Y. H., & Grodzinsky, A. J. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90532-5 · Cited by 1,357
A Blood Vessel Model Constructed from Collagen and Cultured Vascular Cells
Weinberg, C. B., & Bell, E. (1986) · Science · doi:10.1126/science.2934816 · Cited by 1,240
Biodegradable Polymer Scaffolds for Tissue Engineering
Freed, L. E., Vunjak-Novakovic, G., Biron, R. J., Eagles, D. B., Lesnoy, D. C., Barlow, S. K., & Langer, R. (1994) · Nature Biotechnology · doi:10.1038/nbt0794-689 · Cited by 1,235
Self-citation
Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
Ostuni, E., Chapman, R. G., Holmlin, R. E., Takayama, S., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la010384m · Cited by 1,799
Human tissue-engineered blood vessels for adult arterial revascularization
L'Heureux, N., Dusserre, N., Konig, G., Victor, B., Keire, P., Wight, T. N., Chronos, N. A. F., Kyles, A. E., Gregory, C. R., Hoyt, G., et al. (2006) · Nature Medicine · doi:10.1038/nm1364 · Cited by 1,083
Three-Dimensional Cell Culture Matrices: State of the Art
Lee, J., Cuddihy, M. J., & Kotov, N. A. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/teb.2007.0150 · Cited by 1,047
Badylak, S. F., Taylor, D., & Uygun, K. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124743 · Cited by 1,041
Metadata
- Authors
- Niklason, L. E., Gao, J., Abbott, W. M., Hirschi, K. K., Houser, S., Marini, R., & Langer, R.
- Venue
- Science
- Published
- 1999-04-16
- Volume
- 284
- Issue
- 5413
- Pages
- 489-493
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004181539
- Cited by
- 1,766
- References
- 25
- FWCI
- 59.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Niklason, L. E., Gao, J., Abbott, W. M., Hirschi, K. K., Houser, S., Marini, R., & Langer, R. (1999). Functional Arteries Grown in Vitro. Science. https://doi.org/10.1126/science.284.5413.489
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
