The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Abstract
The amyloid β protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the β protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the β protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.
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“Importantly, sequence differences between mice and humans include 3 amino acids within the Aβ sequence (R5G, Y10F and H13R)[155, 174].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [155]
Citations
Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
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Flagged first, then by citations
Research works printed but not linked: 5
- BRADLEY, C.M., TRISOMY 21 1: 41 (1986).
- GLENNER, G, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 107: 218 (1983).
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Cited by
Sorted by citations
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Alzheimer's disease: the amyloid cascade hypothesis
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Metadata
- Authors
- Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L.
- Venue
- Science
- Published
- 1987-02-20
- Volume
- 235
- Issue
- 4791
- Pages
- 880-884
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056046302
- Cited by
- 1,611
- References
- 41
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 19 · 2021: 23 · 2020: 33 · 2019: 31 · 2018: 18 · 2017: 27 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 33 · 2012: 34
- FWCI
- 123.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 00029)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 20118, HD10658)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- amyloid-beta, APP gene, Alzheimer's disease, Down syndrome, chromosome 21, genetic linkage, gene mapping, cerebrovascular amyloid, amyloid plaques, gene dosage
- MeSH terms
- Alzheimer Disease, Amino Acid Sequence, Amyloid, Amyloidosis, Brain, Chromosome Mapping, Chromosomes, Human, Pair 21, DNA, Down Syndrome, Gene Expression Regulation, Humans, Genetic Linkage, RNA, Messenger, Tissue Distribution, Transcription, Genetic
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