The DOI matches its Crossref record.
Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors
Abstract
A novel strategy to determine the clonal origin of human tumors has been devised. The strategy involves the use of a cloned polymorphic X-chromosomal gene and two restriction endonucleases. The first endonuclease distinguishes the paternal and maternal copies of the gene through a DNA polymorphism of restriction fragment length. The second endonuclease distinguishes active from inactive copies of this gene through changes in DNA methylation. As illustrations of this strategy, three human cancers were each shown to be monoclonal. The analysis described should have a wide variety of clinical and experimental applications.
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Citations
Cited by
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443
Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age
Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M., & Gilliland, D. (1996) · Blood · doi:10.1182/blood.v88.1.59.59 · Cited by 543
Thompson, L., Chang, B., & Barsky, S. H. (1996) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199603000-00003 · Cited by 365
Fey, M., Liechti-Gallati, S., von Rohr, A., Borisch, B., Theilkas, L., Schneider, V, Oestreicher, M., Nagel, S., Ziemiecki, A., & Tobler, A. (1994) · Blood · doi:10.1182/blood.v83.4.931.931 · Cited by 138
Clonal analysis of human adrenocortical carcinomas and secreting adenomas
Gicquel, C., Leblond‐Francillard, M., Bertagna, X., Louvel, A., Chapuls, Y., Luton, J., Girard, F., & Le Bouc, Y. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02485.x · Cited by 111
Metadata
- Authors
- Vogelstein, B., Fearon, E. R., Hamilton, S. R., & Feinberg, A. P.
- Venue
- Science
- Published
- 1985-02-08
- Volume
- 227
- Issue
- 4687
- Pages
- 642-645
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982395246
- Cited by
- 380
- References
- 0
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors. https://app.cochat.ai/papers/10.1126/science.2982210
- The paper
- Vogelstein, B., Fearon, E. R., Hamilton, S. R., & Feinberg, A. P. (1985). Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors. Science. https://doi.org/10.1126/science.2982210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
