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Cited by 111Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersNeuroendocrine Tumor Research Advances

Clonal analysis of human adrenocortical carcinomas and secreting adenomas

Gicquel, Christine, Leblond‐Francillard, Marie, Bertagna, Xavier, Louvel, Albert, Chapuls, Yves, Luton, Jean‐Pierre, Girard, François, Le Bouc, Yves·1994·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1994.tb02485.x
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Abstract

OBJECTIVES: Adrenocortical tumours in man are characterized mainly on biochemical, anatomical and histological grounds which establish their secretory pattern and, with some uncertainty, their benign or malignant nature. To study further these tumours and eventually to shed some light on their pathogenesis, we determined their clonal composition. METHODS: Clonal composition was determined by X-chromosome inactivation analysis on tumour and leucocyte DNA using three markers: M27 beta, phospho-glycero-kinase (PGK) and hypoxanthine-phosphoribosyl transferase (HPRT) with 88, 33 and 27% heterozygosity rates respectively. PATIENTS: Clonal analysis was performed on 25 tumours from 19 heterozygous female patients: four had a carcinoma, 14 had a single secreting adenoma, and one had autonomous bilateral macronodular hyperplasia with Cushing's syndrome (seven adenomas examined). RESULTS: The malignant tumours had patterns indicative of monoclonality. The single adenomas displayed contrasting results with patterns indicative of monoclonality in eight cases, and patterns indicative of polyclonality in six cases; monoclonal adenomas were larger and had a higher prevalence of nuclear pleomorphism than the apparently polyclonal adenomas. In the patient with bilateral macronodular hyperplasia, different clonal patterns were present in different adenomas: whereas a clear monoclonal pattern was observed in the three adenomas of the right gland, in which the active X-allele was not always the same, in two interpretable adenomas of the left gland, a moderately skewed pattern suggested a partial monoclonal component. CONCLUSIONS: These data show that adrenocortical carcinomas are monoclonal and suggest that adenomas may arise from a single cell or from more than one cell under the putative action of local growth factors. In adenomas, which until now had appeared homogeneous, this genetic heterogeneity may reflect different pathophysiological mechanisms or it may represent different stages of a common multistep process exceptionally occurring in a single patient with bilateral macronodular hyperplasia.

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  • Most ACAs and all ACCs initiate from monoclonal cell populations, suggesting that mutation events lead to clonal expansion and ultimate progression to cancer.

    “Most ACAs and all ACCs initiate from monoclonal cell populations, suggesting that mutation events lead to clonal expansion and ultimate progression to cancer (177, 178).”

    From Adrenocortical carcinoma (2014) · cites this paper as [178]

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Authors
Gicquel, C., Leblond‐Francillard, M., Bertagna, X., Louvel, A., Chapuls, Y., Luton, J., Girard, F., & Le Bouc, Y.
Affiliations
  • Hôpital Armand-Trousseau (FR)
  • Hôpital Cochin (FR)
Corresponding author
Gicquel, Christine
ORCID
Girard, François
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1994-04
Volume
40
Issue
4
Pages
465-477
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1994.tb02485.x
OpenAlex
W2025619838
Cited by
111
References
46
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2018: 1 · 2016: 2 · 2015: 6 · 2013: 7 · 2012: 4
FWCI
3.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5099 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
adrenocortical carcinoma, adrenal adenoma, clonal composition, X chromosome inactivation, heterozygosity, monoclonality, polyclonality, bilateral macronodular adrenal hyperplasia, Cushing's syndrome, carcinogenesis, genetic heterogeneity, nuclear pleomorphism
MeSH terms
Adenoma, Adolescent, Adrenal Cortex Neoplasms, Adrenal Glands, Adrenal Hyperplasia, Congenital, Adult, Alleles, Autoradiography, Carcinoma, Dosage Compensation, Genetic, Female, Humans, Hypoxanthine Phosphoribosyltransferase, Middle Aged, Phosphoglycerate Kinase, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Blotting, Southern, DNA Probes

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