The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist
Abstract
The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N -methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.
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Citations
Cites
Differential vulnerability of central neurons of the rat to quinolinic acid
Schwarcz, R., & Köhler, C. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90115-5 · Cited by 239
Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
Faden, A. I., Demediuk, P., Panter, S. S., & Vink, R. (1989) · Science · doi:10.1126/science.2567056 · Cited by 1,508
Siesjö, B. K., & Bengtsson, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.20 · Cited by 1,231
The changing landscape of ischaemic brain injury mechanisms
Lee, J.-M., Zipfel, G. J., & Choi, D. W. (1999) · Nature · doi:10.1038/399a007 · Cited by 1,102
Metadata
- Authors
- Wieloch, T.
- Venue
- Science
- Published
- 1985-11-08
- Volume
- 230
- Issue
- 4726
- Pages
- 681-683
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1998164097
- Cited by
- 673
- References
- 1
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wieloch, T. (1985). Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist. Science. https://doi.org/10.1126/science.2996146
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
