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Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis
Abstract
In several bursal lymphoma cell lines in which c- myc transcription is regulated by avian leukosis virus (ALV) long terminal repeat (LTR) sequences, protein synthesis inhibition decreases the transcriptional activity of c- myc as well as other LTR driven viral genes. This decrease in transcription is associated with a change in the chromatin structure of c- myc , as measured by deoxyribonuclease I (DNase I) hypersensitivity, and a shift of transcription from the LTR to the normal c- myc promoter. In contrast, cycloheximide had little or no effect on the transcription of LTR driven genes in infected chicken embryo fibroblasts treated with the drug. These results suggest that a labile, cell type-specific protein may interact with the retroviral LTR and regulate transcription of genes under LTR control. Further, the results demonstrate that the increase in intracellular concentration of c- myc RNA induced by cycloheximide treatment of normal cells is the result of stabilization of this message.
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Cullen, B. R., Raymond, K., & Ju, G. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.3.438-447.1985 · Cited by 87
Cited by
Lau, L. F., & Nathans, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1182 · Cited by 856
Hann, S. R., King, M. W., Bentley, D. L., Anderson, C. W., & Eisenman, R. N. (1988) · Cell · doi:10.1016/0092-8674(88)90507-7 · Cited by 474
The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element
Riegman, P. H. J., Vlietstra, R. J., van der Korput, J. A. G. M., Brinkmann, A. O., & Trapman, J. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1921 · Cited by 451
Feinberg, M. B., Baltimore, D., & Frankel, A. D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.4045 · Cited by 365
Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA
Huang, M. T. F., & Gorman, C. M. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.4.937 · Cited by 303
Metadata
- Authors
- Linial, M., Gunderson, N., & Groudine, M.
- Venue
- Science
- Published
- 1985-12-06
- Volume
- 230
- Issue
- 4730
- Pages
- 1126-1132
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048180296
- Cited by
- 437
- References
- 1
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Linial, M., Gunderson, N., & Groudine, M. (1985). Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis. Science. https://doi.org/10.1126/science.2999973
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
