Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Lau, L F; Nathans, D

doi:10.1073/pnas.84.5.1182

Cited by 856Protein Kinase Regulation and GTPase SignalingGenomics and Chromatin DynamicsCancer-related Molecular Pathways

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Open access

Lau, L F, Nathans, D·1987·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.84.5.1182PMC PMC304390

Open this paper in CoChat — free account

Abstract

We have previously identified by cDNA cloning 5 mRNAs that appear in resting BALB/c 3T3 cells soon after growth stimulation by serum or platelet-derived growth factor. Five additional mRNAs of this class are described in this report. The mRNAs reached peak levels between 40 and 120 min after serum addition and rapidly decayed thereafter. All 10 RNAs were superinduced in the presence of cycloheximide. Nuclear run-on experiments indicated that the increase in the mRNAs is the result of rapid transcriptional activation of their genes on stimulation by serum or platelet-derived growth factor. Superinducibility by cycloheximide is due to two effects: prolonged transcription and stabilization of mRNAs. This overall pattern of regulation is similar to that of the c-fos or c-myc protooncogenes reported previously. We hypothesize that these newly identified "immediate early" genes play a role in the proliferative response induced by growth factors.

Integrity signals

Registry

Crossref · 10.1073/pnas.84.5.1182

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

CCN1 is an immediate-early gene expressed at very low levels in quiescent fibroblasts and is transcriptionally activated within minutes by serum growth factors without requiring new protein synthesis.
“CCN1 is an immediate-early gene expressed at a very low level in quiescent fibroblasts, but is transcriptionally activated within minutes of stimulation by serum growth factors without requiring de novo protein synthesis [5,6].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [6]

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works
Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose
Aviv, H., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1408 · Cited by 6,636 · see citing works
A simple and very efficient method for generating cDNA libraries
Gubler, U., & Hoffman, B. J. (1983) · Gene · doi:10.1016/0378-1119(83)90230-5 · Cited by 4,461 · see citing works
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946 · see citing works
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804 · see citing works
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M., & Ziff, E. (1984) · Nature · doi:10.1038/311433a0 · Cited by 2,650 · see citing works
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,296 · see citing works
Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes
Cleveland, D. W., Lopata, M. A., MacDonald, R. J., Cowan, N. J., Rutter, W. J., & Kirschner, M. W. (1980) · Cell · doi:10.1016/0092-8674(80)90238-x · Cited by 1,835 · see citing works
Early Signals in the Mitogenic Response
Rozengurt, E. (1986) · Science · doi:10.1126/science.3018928 · Cited by 1,473 · see citing works
Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins
Honess, R. W., & Roizman, B. (1974) · Journal of Virology · doi:10.1128/jvi.14.1.8-19.1974 · Cited by 1,415 · see citing works
The long and the short of long–term memory—a molecular framework
Goelet, P., Castellucci, V. F., Schacher, S., & Kandel, E. R. (1986) · Nature · doi:10.1038/322419a0 · Cited by 1,041 · see citing works
Role of ion flux in the control of c-fos expression
Morgan, J. I., & Curran, T. (1986) · Nature · doi:10.1038/322552a0 · Cited by 998 · see citing works
Molecular cloning of gene sequences regulated by platelet-derived growth factor
Cochran, B., Reffel, A. C., & Stiles, C. D. (1983) · Cell · doi:10.1016/0092-8674(83)90037-5 · Cited by 988 · see citing works
Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors
Treisman, R. (1986) · Cell · doi:10.1016/0092-8674(86)90882-2 · Cited by 886 · see citing works
Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences
Treisman, R. (1985) · Cell · doi:10.1016/0092-8674(85)90285-5 · Cited by 839 · see citing works
Transcriptional Regulation of Hemoglobin Switching in Chicken Embryos
Groudine, M. T., Peretz, M., & Weintraub, H. M. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.3.281 · Cited by 777 · see citing works
Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription
Greenberg, M. E., Ziff, E. B., & Greene, L. A. (1986) · Science · doi:10.1126/science.3749894 · Cited by 761 · see citing works
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation
Campisi, J., Gray, H. E., Pardee, A. B., Dean, M. C., & Sonenshein, G. E. (1984) · Cell · doi:10.1016/0092-8674(84)90217-4 · Cited by 747 · see citing works
Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process
Pledger, W. J., Stiles, C. D., Antoniades, H. N., & Scher, C. D. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4481 · Cited by 675 · see citing works
c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene
Miller, A. D., Curran, T., & Verma, I. M. (1984) · Cell · doi:10.1016/0092-8674(84)90073-4 · Cited by 601 · see citing works
Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.
Goldberg, D. A. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.10.5794 · Cited by 571 · see citing works
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
Lau, L. F., & Nathans, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04057.x · Cited by 567 · see citing works
Self-citation
Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.
Greenberg, M. E., Hermanowski, A. L., & Ziff, E. B. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.4.1050 · Cited by 549 · see citing works
Extreme instability of myc mRNA in normal and transformed human cells.
Dani, C., Blanchard, J., Piechaczyk, M., SABOUTY, S. E., Marty, L., & Jeanteur, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.22.7046 · Cited by 517 · see citing works
Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis
Linial, M. L., Gunderson, N., & Groudine, M. T. (1985) · Science · doi:10.1126/science.2999973 · Cited by 451 · see citing works
Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.
Holt, J. T., Gopal, T. V., Moulton, A. D., & Nienhuis, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4794 · Cited by 439 · see citing works
POLYPEPTIDE GROWTH FACTORS
James, R. B., & Bradshaw, R. A. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.001355 · Cited by 376 · see citing works
Microinjected c- myc as a Competence Factor
Kaczmarek, L., Hyland, J. K., Watt, R. A., et al. (1985) · Science · doi:10.1126/science.4001943 · Cited by 360 · see citing works
Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.
Matrisian, L. M., Glaichenhaus, N., Gesnel, M.-C., & Breathnach, R. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03799.x · Cited by 333 · see citing works
Participation of c- myc Protein in DNA Synthesis of Human Cells
Studzinski, G. P., Brelvi, Z., Feldman, S. C., et al. (1986) · Science · doi:10.1126/science.3532322 · Cited by 277 · see citing works
Metabolism of c‐myc gene products: c‐myc mRNA and protein expression in the cell cycle.
Rabbitts, P. H., Watson, J. E. M., Lamond, A. I., et al. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03885.x · Cited by 271 · see citing works
Transcriptional Regulation of Hemoglobin Switching in Chicken Embryos
Groudine, M. T., Peretz, M., & Weintraub, H. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.3.281-288.1981 · Cited by 270 · see citing works
Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells
Zullo, J. N., Cochran, B., Huang, A., et al. (1985) · Cell · doi:10.1016/0092-8674(85)90252-1 · Cited by 262 · see citing works
Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide.
Elder, P. K., Schmidt, L. J., Ono, T., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.23.7476 · Cited by 215 · see citing works
Growth-related changes in specific mRNAs of cultured mouse cells.
Linzer, D. I. H., & Nathans, D. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4271 · Cited by 209 · see citing works
Self-citation
Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.
Meijlink, F. C. P. W., Curran, T., Miller, A. D., et al. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.15.4987 · Cited by 208 · see citing works
Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.
Larner, A. C., Chaudhuri, A., & Darnell, J. E., Jr. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42492-6 · Cited by 205 · see citing works
Isolation of cloned cDNA encoding mammalian ornithine decarboxylase.
Kahana, C., & Nathans, D. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3645 · Cited by 202 · see citing works
Self-citation
Cell-cycle-specific cDNAs from mammalian cells temperature sensitive for growth.
Hirschhorn, R. R., Aller, P., Yuan, Z., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6004 · Cited by 195 · see citing works
Mediators in cell growth and differentiation.
Ford, R. J., & Maizel, A. (1984) · PubMed · Cited by 169 · see citing works
Transcription during bacteriophage T4 development: A demonstration that distinct subclasses of the “early” RNA appear at different times and that some are “turned off” at late times
Salser, W. A., Bolle, A., & Epstein, R. H. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90246-9 · Cited by 144 · see citing works
Transcriptional and translational control of cytoplasmic proteins after serum stimulation of quiescent Swiss 3T3 cells.
Thomas, G., Thomas, G., & Luther, H. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5712 · Cited by 138 · see citing works
Effect of Protein Synthesis Inhibitors on Growth Factor Activation of c-fos, c-myc, and Actin Gene Transcription
Greenberg, M. E., Hermanowski, A. L., & Ziff, E. B. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.4.1050-1057.1986 · Cited by 132 · see citing works
Platelet-derived growth factor-modulated proteins: constitutive synthesis by a transformed cell line.
Pledger, W. J., Hart, C. A., Locatell, K. L., & Scher, C. D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4358 · Cited by 122 · see citing works
Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth.
Croy, R. G., & Pardee, A. B. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.15.4699 · Cited by 112 · see citing works
Neurobiology: Second messenger dualism in neuromodulation and memory
Berridge, M. J. (1986) · Nature · doi:10.1038/323294a0 · Cited by 97 · see citing works
Regulation of human histone gene expression during the HeLa cell cycle requires protein synthesis.
Sive, H. L., Heintz, N., & Roeder, R. G. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.12.2723 · Cited by 92 · see citing works
Polyadenylylated RNA complementary to a mouse retrovirus-like multigene family is rapidly and specifically induced by epidermal growth factor stimulation of quiescent cells.
Foster, D. N., Schmidt, L. J., Hodgson, C. P., et al. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7317 · Cited by 77 · see citing works
Synthesis of Early RNA in Bacteriophage T4-infected Escherichia coli B
Grasso, R. J., & Buchanan, J. M. (1969) · Nature · doi:10.1038/224882a0 · Cited by 67 · see citing works
Identification of a BALB/c-3T3 cell protein modulated by platelet-derived growth factor.
Scher, C. D., Dick, R., Whipple, A. P., et al. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.1.70 · Cited by 50 · see citing works
Regulation of Human Histone Gene Expression During the HeLa Cell Cycle Requires Protein Synthesis
Sive, H. L., Heintz, N., & Roeder, R. G. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.12.2723-2734.1984 · Cited by 48 · see citing works
Metabolism of mRNA from the Transforming Region of Adenovirus 2Preprint
Wilson, M. C., Nevins, J. R., Blanchard, J. M., et al. (1980) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1980.044.01.048 · Cited by 45 · see citing works
cDNA cloning of mRNAS which increase rapidly in human lymphocytes cultured with concanavalin-A and cycloheximide
Forsdyke, D. R. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91936-9 · Cited by 40 · see citing works
Platelet-derived growth factor-modulated translatable mRNAs.
Hendrickson, S. L., & Scher, C. D. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.8.1478 · Cited by 30 · see citing works
A simple relationship between maximal aerobic power and body weight in Indian adolescent boys.
Ss, V., Rk, G., Kishore, N. T. K., et al. (1986) · PubMed · Cited by 18 · see citing works
Platelet-Derived Growth Factor-Modulated Translatable mRNAs
Hendrickson, S. L., & Scher, C. D. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.8.1478-1487.1983 · Cited by 12 · see citing works
Identification of a BALB/c-3T3 Cell Protein Modulated by Platelet-Derived Growth Factor
Scher, C. D., Dick, R. L., Whipple, A. P., et al. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.1.70-81.1983 · Cited by 12 · see citing works

Flagged first, then by citations

Sorted by citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1
Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., & Tjian, R. (1987) · Science · doi:10.1126/science.2825349 · Cited by 1,321 · see citing works
The c-Myc target gene network
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188 · see citing works
Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03993.2000 · Cited by 992 · see citing works
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF
Isackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711 · see citing works
Cell cycle dependent regulation of phosphorylation of the human retinoblastoma gene product
Mihara, K., Cao, X.-R., Yen, A., Chandler, S., Driscoll, B., Murphree, A. L., T'Ang, A., & Fung, Y.-K. (1989) · Science · doi:10.1126/science.2588006 · Cited by 449 · see citing works
The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage
Nguyen, H. Q., Hoffman-Liebermann, B., & Liebermann, D. A. (1993) · Cell · doi:10.1016/0092-8674(93)90660-i · Cited by 367 · see citing works
Ets ternary complex transcription factors
Buchwalter, G., Gross, C., & Wasylyk, B. (2004) · Gene · doi:10.1016/j.gene.2003.09.028 · Cited by 336 · see citing works
CCN1/CYR61: the very model of a modern matricellular protein
Lau, L. F. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0778-3 · Cited by 338 · see citing works
Self-citation
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310 · see citing works
Self-citation
The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts
Chen, C.-C., Chen, N., & Lau, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008087200 · Cited by 305 · see citing works
Self-citation
CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.
Greenbaum, L. E., Li, W., Cressman, D. E., Peng, Y., Ciliberto, G., Poli, V, & Taub, R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3135 · Cited by 270 · see citing works
Adhesion of Human Umbilical Vein Endothelial Cells to the Immediate-Early Gene Product Cyr61 Is Mediated through Integrin αvβ3
Kireeva, M. L., Lam, S. C.-T., & Lau, L. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.3090 · Cited by 203 · see citing works
Self-citation
Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.
Murano, S., Thweatt, R., Shmookler Reis, R. J., Jones, R. A., Moerman, E. J., & Goldstein, S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.3905 · Cited by 199 · see citing works
The role of transferrin in the mechanism of cellular iron uptake
Thorstensen, K., & Romslo, I. (1990) · Biochemical Journal · doi:10.1042/bj2710001 · Cited by 194 · see citing works
Cyr61, Product of a Growth Factor-Inducible Immediate-Early Gene, Regulates Chondrogenesis in Mouse Limb Bud Mesenchymal Cells
Wong, M., Kireeva, M. L., Kolesnikova, T. V., & Lau, L. F. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8766 · Cited by 155 · see citing works
Self-citation
Induced differentiation of K562 leukemia cells: A model for studies of gene expression in early megakaryoblasts
Alitalo, R. (1990) · Leukemia Research · doi:10.1016/0145-2126(90)90002-q · Cited by 152 · see citing works
Breast Cancer
Xie, D., Miller, C. W., O'Kelly, J., Nakachi, K., Sakashita, A., Said, J. W., Gornbein, J., & Koeffler, H. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009755200 · Cited by 146 · see citing works
Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues
Mcmahon, A. P., Champion, J. E., Mcmahon, J. A., & Sukhatme, V. P. (1990) · Development · doi:10.1242/dev.108.2.281 · Cited by 141 · see citing works
Expression of CYR61, an Angiogenic Immediate Early Gene, in Arteriosclerosis and Its Regulation by Angiotensin II
Hilfiker, A., Hilfiker-Kleiner, D., Fuchs, M., Kaminski, K., Lichtenberg, A., Rothkötter, H.-J., Schieffer, B., & Drexler, H. (2002) · Circulation · doi:10.1161/01.cir.0000021426.87274.62 · Cited by 114 · see citing works
Temporal Expression of the Chondrogenic and Angiogenic Growth Factor CYR61 During Fracture Repair
Hadjiargyrou, M., Ahrens, W., & Rubin, C. T. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1014 · Cited by 110 · see citing works
The cellular response to induction of the p21 c‐Ha‐ras oncoprotein includes stimulation of jun gene expression.
Sistonen, L., Hölttä, E., Mäkelä, T. P., Keski‐Oja, J., & Alitalo, K. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03442.x · Cited by 109 · see citing works
The response of c-Jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1α dependent
Laderoute, K. R., Calaoagan, J. M., Gustafson-Brown, C., Knapp, A. M., Li, G.-C., Mendonca, H. L., Ryan, H. E., Wang, Z., & Johnson, R. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2515-2523.2002 · Cited by 105 · see citing works
Cyr61, a deregulated gene in endometriosis
Absenger, Y. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah053 · Cited by 95 · see citing works
Promoter function and structure of the growth factorinducible immediate early genecyr61
Latinkic, B. V., Brien, T. P. O., & Lau, L. F. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.12.3261 · Cited by 87 · see citing works
Self-citation
Induced Endometriosis in the Baboon (Papio anubis) Increases the Expression of the Proangiogenic Factor CYR61 (CCN1) in Eutopic and Ectopic Endometria1
Gashaw, I., Hastings, J. M., Jackson, K. S., Winterhager, E., & Fazleabas, A. T. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.049320 · Cited by 81 · see citing works
Promoter Function of the Angiogenic Inducer Cyr61Gene in Transgenic Mice: Tissue Specificity, Inducibility During Wound Healing, and Role of the Serum Response Element
Latinkic, B. V. (2001) · Endocrinology · doi:10.1210/en.142.6.2549 · Cited by 61 · see citing works
Expression of c-jun during macrophage differentiation of HL-60 cells
Gaynor, R., Simon, K., & Koeffler, P. (1991) · Blood · doi:10.1182/blood.v77.12.2618.2618 · Cited by 59 · see citing works
Stimulation of Angiogenesis by Cyr61 Gene: A New Therapeutic Candidate
Fataccioli, V., Abergel, V., Wingertsmann, L., Neuville, P., Spitz, E., Adnot, S., Calenda, V., & Teiger, E. (2002) · Human Gene Therapy · doi:10.1089/10430340260185094 · Cited by 58 · see citing works
Proto-Oncogenes of the fos/jun Family of Transcription Factors are Positive Regulators of Myeloid Differentiation
Lord, K. A., Abdollahi, A., Hoffman-Liebermann, B., & Liebermann, D. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.841-851.1993 · Cited by 54 · see citing works
Cryopreservation of microglia enables single-cell RNA sequencing with minimal effects on disease-related gene expression patterns
Morsey, B., Niu, M., Dyavar, S. R., Fletcher, C. V., Lamberty, B. G., Emanuel, K., Fangmeier, A., & Fox, H. S. (2021) · iScience · doi:10.1016/j.isci.2021.102357 · Cited by 25 · see citing works

Cycloheximide or puromycin can substitute for PDGF in inducing cellular DNA synthesis in quiescent 3T3 cells
Kaczmarek, L., Surmacz, E., & Baserga, R. (1986) · Cell Biology International Reports · doi:10.1016/0309-1651(86)90041-x · Cited by 20 · see citing works
Effects of Formalin Pain on Hippocampal c-Fos Expression in Male and Female Rats
Ceccarelli, I., Scaramuzzino, A., & Aloisi, A. M. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00145-8 · Cited by 29 · see citing works
Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning
Yasoshima, Y., Sako, N., Senba, E., & Yamamoto, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600869103 · Cited by 72 · see citing works
[DNA synthesis in the nuclei of stimulated NIH 3T3 cells in heterodikaryons obtained by the fusion of these cells with resting cells treated with cycloheximide].
Setkov, N. A., & Kazakov, V. N. (1989) · PubMed
Measurement of Immediate‐Early Gene Activation‐ c‐fos and Beyond
Kovács, K. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01734.x · Cited by 493 · see citing works

Authors: Lau, L. F., & Nathans, D.
Affiliations: Johns Hopkins University (US)
ORCID: Lau, L F
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1987-03
Volume: 84
Issue: 5
Pages: 1182-1186
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.84.5.1182
PMC: PMC304390
OpenAlex: W2077492124
Cited by: 856
References: 57
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 7 · 2012: 12
FWCI: 29.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Profiles in Science (submittedVersion)
Funders: Helen Hay Whitney Foundation
National Cancer Institute (P01CA016519, 5 P01 CA-16519)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: immediate early genes, growth-related genes, BALB/c 3T3 cells, serum stimulation, platelet-derived growth factor, c-fos, c-Myc, proto-oncogenes, transcriptional activation, mRNA stabilization, cell proliferation, gene expression regulation
MeSH terms: Animals, Cells, Cultured, Cycloheximide, Gene Expression Regulation, Genes, Mice, Inbred BALB C, Nucleic Acid Hybridization, Proto-Oncogenes, RNA, Messenger, Transcription, Genetic, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks