The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein
Abstract
Cleavage of phosphatidylinositol 4,5-bisphosphate by phospholipase C results in the production of two important second messengers: inositol-1,4,5-trisphosphate and 1,2-diacylglycerol. Although several receptors promote this cleavage, the molecular details of phospholipase C activation have remained unresolved. In this study, occupancy of a Ca 2+ -mobilizing receptor, the oligopeptide chemoattractant receptor on human polymorphonuclear leukocyte plasma membranes, was found to lead to the activation of a guanine nucleotide regulatory (N) protein by guanosine 5′-triphosphate. The activated N protein then stimulated a polyphosphoinositide-specific phospholipase C by reducing the Ca 2+ requirement for expression of this activity from superphysiological to normal intracellular concentrations. Therefore, the N protein-mediated activation of phospholipase C may be a key step in the pathway of cellular activation by chemoattractants and certain other hormones.
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Citations
Cites
The role of protein kinase C in cell surface signal transduction and tumour promotion
Nishizuka, Y. (1984) · Nature · doi:10.1038/308693a0 · Cited by 7,454
Inositol Trisphosphate, a Novel Second Messenger in Cellular Signal Transduction
Berridge, M. J., & Irvine, R. F. (1984) · Nature · doi:10.1038/312315a0 · Cited by 6,086
Inositol trisphosphate and diacylglycerol as second messengers
Berridge, M. J. (1984) · Biochemical Journal · doi:10.1042/bj2200345 · Cited by 3,516
G proteins and dual control of adenylate cyclase
Gilman, A. G. (1984) · Cell · doi:10.1016/0092-8674(84)90336-2 · Cited by 1,802
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
Rodbell, M. (1980) · Nature · doi:10.1038/284017a0 · Cited by 1,749
Berridge, M. J. (1983) · Biochemical Journal · doi:10.1042/bj2120849 · Cited by 1,110
Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors
Gomperts, B. D. (1983) · Nature · doi:10.1038/306064a0 · Cited by 466
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
Bokoch, G. M., & Gilman, A. G. (1984) · Cell · doi:10.1016/0092-8674(84)90008-4 · Cited by 422
Okajima, F., & Ui, M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89826-x · Cited by 387
Smith, C. D., Lane, B. C., Kusaka, I., Verghese, M. W., & Snyderman, R. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88907-4 · Cited by 355
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Cited by
Receptor-effector coupling by G proteins
Birnbaumer, L., Abramowitz, J., & Brown, A. M. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90007-y · Cited by 1,118
Burch, R. M., Luini, A., & Axelrod, J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7201 · Cited by 425
Role of Calcium in Angiotensin II-Mediated Aldosterone Secretion*
BARRETT, P. Q., BOLLAG, W. B., ISALES, C. M., MCCARTHY, R. T., & RASMUSSEN, H. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-4-496 · Cited by 183
Metadata
- Authors
- Smith, C. D., Cox, C. C., & Snyderman, R.
- Venue
- Science
- Published
- 1986-04-04
- Volume
- 232
- Issue
- 4746
- Pages
- 97-100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993574643
- Cited by
- 324
- References
- 23
- FWCI
- 24.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
