The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating
Abstract
WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the p H-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 β-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.
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Cites
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Structure of a human common cold virus and functional relationship to other picornaviruses
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Self-citationThree-Dimensional Structure of Poliovirus at 2.9 Å Resolution
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Self-citationThe complete nucleotide sequence of a common cold virus: human rhinovlrus 14
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Self-citationPrevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug
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Self-citationThe Molecular Biology of Poliovirus
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Cited by
Activity of Pleconaril against Enteroviruses
Pevear, D. C., Tull, T. M., Seipel, M. E., & Groarke, J. M. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.9.2109 · Cited by 368
The Atomic Structure of Mengo Virus at 3.0 Å Resolution
Luo, M., Vriend, G., Kamer, G., Minor, I., Arnold, E., Rossmann, M. G., Boege, U., Scraba, D. G., Duke, G. M., & Palmenberg, A. C. (1987) · Science · doi:10.1126/science.3026048 · Cited by 357
Self-citationIdentification of native protein folds amongst a large number of incorrect models
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Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine
Marsian, J., Fox, H., Bahar, M. W., Kotecha, A., Fry, E. E., Stuart, D. I., Macadam, A. J., Rowlands, D. J., & Lomonossoff, G. P. (2017) · Nature Communications · doi:10.1038/s41467-017-00090-w · Cited by 121
Complexes of poliovirus serotypes with their common cellular receptor, CD155
He, Y., Mueller, S., Chipman, P. R., Bator, C. M., Peng, X., Bowman, V. D., Mukhopadhyay, S., Wimmer, E., Kuhn, R. J., & Rossmann, M. G. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4827-4835.2003 · Cited by 98
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Metadata
- Authors
- Smith, T. J., Kremer, M. J., Luo, M., Vriend, G., Arnold, E., Kamer, G., Rossmann, M. G., McKinlay, M. A., Diana, G. D., & Otto, M. J.
- Venue
- Science
- Published
- 1986-09-19
- Volume
- 233
- Issue
- 4770
- Pages
- 1286-1293
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084352383
- Cited by
- 455
- References
- 20
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, T. J., Kremer, M. J., Luo, M., Vriend, G., Arnold, E., Kamer, G., Rossmann, M. G., McKinlay, M. A., Diana, G. D., & Otto, M. J. (1986). The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating. Science. https://doi.org/10.1126/science.3018924
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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