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The Metabolism of Phosphoinositide-Derived Messenger Molecules
Abstract
The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.
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Citations
Cited by
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.415 · Cited by 501
Hormone-evoked calcium release from intracellular stores is a quantal process
Muallem, S., Pandol, S. J., & Beeker, T. G. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31244-9 · Cited by 307
Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
Khan, W. A., Blobe, G. C., & Hannun, Y. A. (1995) · Cellular Signalling · doi:10.1016/0898-6568(94)00089-t · Cited by 225
Metadata
- Authors
- Majerus, P. W., Connolly, T. M., Deckmyn, H., Ross, T. S., Bross, T. E., Ishii, H., Bansal, V. S., & Wilson, D. B.
- Venue
- Science
- Published
- 1986-12-19
- Volume
- 234
- Issue
- 4783
- Pages
- 1519-1526
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078411762
- Cited by
- 715
- References
- 0
- FWCI
- 42.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Majerus, P. W., Connolly, T. M., Deckmyn, H., Ross, T. S., Bross, T. E., Ishii, H., Bansal, V. S., & Wilson, D. B. (1986). The Metabolism of Phosphoinositide-Derived Messenger Molecules. Science. https://doi.org/10.1126/science.3024320
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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