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The Regulation of Natural Anticoagulant Pathways
Abstract
Vascular endothelium plays an active role in preventing blood clot formation in vivo. One mechanism by which prevention is achieved involves a cell surface thrombin-binding protein, thrombomodulin, which converts thrombin into a protein C activator. Activated protein C then functions as an anticoagulant by inactivating two regulatory proteins of the coagulation system, factors Va and VIIIa. The physiological relevance of the protein C anticoagulant pathway is demonstrated by the identification of homozygous protein C-deficient infants with severe thrombotic complications. Recent studies suggest that this pathway provides a link between inflammation and coagulation.
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Cited by
Lentz, S. R., & Sadler, J. E. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115514 · Cited by 448
Rodgers, G., & Conn, M. (1990) · Blood · doi:10.1182/blood.v75.4.895.895 · Cited by 398
Flow-induced stress on adherent cells in microfluidic devices
Shemesh, J., Jalilian, I., Shi, A., Heng Yeoh, G., Knothe Tate, M. L., & Ebrahimi Warkiani, M. (2015) · Lab on a Chip · doi:10.1039/c5lc00633c · Cited by 144
Infections and endothelial cells
Keller, T. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00354-7 · Cited by 116
Jeremic, K., Pervulov, M., Gojnic, M., Dukanac, J., Ljubic, A., & Stojnic, J. (2005) · Vojnosanitetski pregled · doi:10.2298/vsp0506435j · Cited by 20
Metadata
- Authors
- Esmon, C. T.
- Venue
- Science
- Published
- 1987-03-13
- Volume
- 235
- Issue
- 4794
- Pages
- 1348-1352
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2106352950
- Cited by
- 697
- References
- 0
- FWCI
- 23.86
- Type
- journal article
- Language
- en
- Open access
- closed
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